1 Ocak 2021 Dergi makalesi Açık Erişim

Duyar, Halil; Portakal, Huseyin S.; Yalcin, Ergin; Kanat, Beyza; Doluca, Osman; Seferoglu, Zeynel

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{
  "@context": "https://schema.org/", 
  "@id": 237424, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Duyar, Halil"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Izmir Univ Econ, Dept Biomed Engn, TR-35330 Izmir, Turkey", 
      "name": "Portakal, Huseyin S."
    }, 
    {
      "@type": "Person", 
      "name": "Yalcin, Ergin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Izmir Univ Econ, Dept Biomed Engn, TR-35330 Izmir, Turkey", 
      "name": "Kanat, Beyza"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Izmir Univ Econ, Dept Biomed Engn, TR-35330 Izmir, Turkey", 
      "name": "Doluca, Osman"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Dept Chem, TR-06560 Ankara, Turkey", 
      "name": "Seferoglu, Zeynel"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.", 
  "headline": "Fluorene/fluorenone carboxamide derivatives as selective light-up fluorophores for c-myc G-quadruplex", 
  "identifier": 237424, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Fluorene/fluorenone carboxamide derivatives as selective light-up fluorophores for c-myc G-quadruplex", 
  "url": "https://aperta.ulakbim.gov.tr/record/237424"
}