1 Ocak 2021 Dergi makalesi Açık Erişim

Duyar, Halil; Portakal, Huseyin S.; Yalcin, Ergin; Kanat, Beyza; Doluca, Osman; Seferoglu, Zeynel

Citation Style Language JSON

{
  "DOI": "10.1016/j.bmcl.2021.127824", 
  "abstract": "The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.", 
  "author": [
    {
      "family": "Duyar", 
      "given": " Halil"
    }, 
    {
      "family": "Portakal", 
      "given": " Huseyin S."
    }, 
    {
      "family": "Yalcin", 
      "given": " Ergin"
    }, 
    {
      "family": "Kanat", 
      "given": " Beyza"
    }, 
    {
      "family": "Doluca", 
      "given": " Osman"
    }, 
    {
      "family": "Seferoglu", 
      "given": " Zeynel"
    }
  ], 
  "container_title": "BIOORGANIC & MEDICINAL CHEMISTRY LETTERS", 
  "id": "237424", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Fluorene/fluorenone carboxamide derivatives as selective light-up fluorophores for c-myc G-quadruplex", 
  "type": "article-journal", 
  "volume": "36"
}