1 Ocak 2021 Dergi makalesi Açık Erişim

Duyar, Halil; Portakal, Huseyin S.; Yalcin, Ergin; Kanat, Beyza; Doluca, Osman; Seferoglu, Zeynel

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/237424</identifier>
  <creators>
    <creator>
      <creatorName>Duyar, Halil</creatorName>
      <givenName>Halil</givenName>
      <familyName>Duyar</familyName>
    </creator>
    <creator>
      <creatorName>Portakal, Huseyin S.</creatorName>
      <givenName>Huseyin S.</givenName>
      <familyName>Portakal</familyName>
      <affiliation>Izmir Univ Econ, Dept Biomed Engn, TR-35330 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yalcin, Ergin</creatorName>
      <givenName>Ergin</givenName>
      <familyName>Yalcin</familyName>
    </creator>
    <creator>
      <creatorName>Kanat, Beyza</creatorName>
      <givenName>Beyza</givenName>
      <familyName>Kanat</familyName>
      <affiliation>Izmir Univ Econ, Dept Biomed Engn, TR-35330 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Doluca, Osman</creatorName>
      <givenName>Osman</givenName>
      <familyName>Doluca</familyName>
      <affiliation>Izmir Univ Econ, Dept Biomed Engn, TR-35330 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Seferoglu, Zeynel</creatorName>
      <givenName>Zeynel</givenName>
      <familyName>Seferoglu</familyName>
      <affiliation>Gazi Univ, Dept Chem, TR-06560 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Fluorene/Fluorenone Carboxamide Derivatives As Selective Light-Up Fluorophores For C-Myc G-Quadruplex</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/237424</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.bmcl.2021.127824</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.</description>
  </descriptions>
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