1 Ocak 2021 Dergi makalesi Açık Erişim

Duyar, Halil; Portakal, Huseyin S.; Yalcin, Ergin; Kanat, Beyza; Doluca, Osman; Seferoglu, Zeynel

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        "name": "Duyar, Halil"
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      {
        "affiliation": "Izmir Univ Econ, Dept Biomed Engn, TR-35330 Izmir, Turkey", 
        "name": "Portakal, Huseyin S."
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      {
        "name": "Yalcin, Ergin"
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      {
        "affiliation": "Izmir Univ Econ, Dept Biomed Engn, TR-35330 Izmir, Turkey", 
        "name": "Kanat, Beyza"
      }, 
      {
        "affiliation": "Izmir Univ Econ, Dept Biomed Engn, TR-35330 Izmir, Turkey", 
        "name": "Doluca, Osman"
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      {
        "affiliation": "Gazi Univ, Dept Chem, TR-06560 Ankara, Turkey", 
        "name": "Seferoglu, Zeynel"
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    "description": "The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.", 
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      "title": "BIOORGANIC & MEDICINAL CHEMISTRY LETTERS", 
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    "title": "Fluorene/fluorenone carboxamide derivatives as selective light-up fluorophores for c-myc G-quadruplex"
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