Dergi makalesi Açık Erişim

Fluorene/fluorenone carboxamide derivatives as selective light-up fluorophores for c-myc G-quadruplex

2021    Duyar, Halil; Portakal, Huseyin S.; Yalcin, Ergin; Kanat, Beyza; Doluca, Osman; Seferoglu, Zeynel

The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.