1 Ocak 2021 Dergi makalesi Açık Erişim

Gozalan, Aysegul; Unaldi, Ozlem; Guldemir, Dilek; Aydogan, Sibel; Kuzucu, Cigdem; Cakirlar, Fatma Koksal; Acikgoz, Ziya Cibali; Durmaz, Riza

Dublin Core

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  <dc:creator>Gozalan, Aysegul</dc:creator>
  <dc:creator>Unaldi, Ozlem</dc:creator>
  <dc:creator>Guldemir, Dilek</dc:creator>
  <dc:creator>Aydogan, Sibel</dc:creator>
  <dc:creator>Kuzucu, Cigdem</dc:creator>
  <dc:creator>Cakirlar, Fatma Koksal</dc:creator>
  <dc:creator>Acikgoz, Ziya Cibali</dc:creator>
  <dc:creator>Durmaz, Riza</dc:creator>
  <dc:date>2021-01-01</dc:date>
  <dc:description>We aimed to investigate the clonal relationships, common sequence types, and carbapenemase genes in 177 non-repetitive blood culture isolates of Acinetobacter baumannii collected from patients at three university hospitals in Turkey in 2016. Molecular epidemiological characteristics of the isolates were examined using pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST) (Pasteur scheme-cpn60, fusA, gltA, pyrG, recA, rplB, and rpoB). Multiplex PCR was used to investigate the carbapenemase genes, including bla(OXA-23-like),bla(OXA-24-like), bla(OXA-48-like), bla(OXA-58-like), bla(IMP), bla(VIM) and bla(NDm). PFGE genotyping yielded 92 pulsotypes with a clustering ratio of 69.7%. As per a &gt;= 85% similarity coefficient, 159 (90.9%) isolates were found to be clonally related. The bla(OXA-)(23-like) and bla(OXA-)(58)-like genes were identified in 100% and 28.2% of the isolates, respectively. The bla(NDM) gene was identified in two isolates. The MLST analysis included 54 isolates with different pulsotypes, and 29 sequence types (STs). Most of the isolates (n = 36) belonged to the clonal complex (CC)2, one isolate belonged to CC1, and one isolate belonged to CC164. Sixteen new STs (ST1235-ST1250) were identified. Identifying both global ST2 and a large number of new STs, revealed high genetic diversity in A. baumannii isolates in the study population.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/233202</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:233202</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JAPANESE JOURNAL OF INFECTIOUS DISEASES 74(3) 200-208</dc:source>
  <dc:title>Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii Blood Culture Isolates from Three Hospitals in Turkey</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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