1 Ocak 2021 Dergi makalesi Açık Erişim

Gozalan, Aysegul; Unaldi, Ozlem; Guldemir, Dilek; Aydogan, Sibel; Kuzucu, Cigdem; Cakirlar, Fatma Koksal; Acikgoz, Ziya Cibali; Durmaz, Riza

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/233202</identifier>
  <creators>
    <creator>
      <creatorName>Gozalan, Aysegul</creatorName>
      <givenName>Aysegul</givenName>
      <familyName>Gozalan</familyName>
      <affiliation>Alanya Alaaddin Keykubat Univ, Fac Med, Dept Med Microbiol, TR-07400 Antalya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Unaldi, Ozlem</creatorName>
      <givenName>Ozlem</givenName>
      <familyName>Unaldi</familyName>
      <affiliation>Minist Hlth, Natl Mol Microbiol Reference Lab, Publ Hlth Gen Directorate, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guldemir, Dilek</creatorName>
      <givenName>Dilek</givenName>
      <familyName>Guldemir</familyName>
      <affiliation>Minist Hlth, Natl Mol Microbiol Reference Lab, Publ Hlth Gen Directorate, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aydogan, Sibel</creatorName>
      <givenName>Sibel</givenName>
      <familyName>Aydogan</familyName>
      <affiliation>Minist Hlth, Dept Med Microbiol, Ankara City Hosp, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kuzucu, Cigdem</creatorName>
      <givenName>Cigdem</givenName>
      <familyName>Kuzucu</familyName>
      <affiliation>Tinaztepe Izmir Univ, Fac Med, Dept Med Microbiol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cakirlar, Fatma Koksal</creatorName>
      <givenName>Fatma Koksal</givenName>
      <familyName>Cakirlar</familyName>
      <affiliation>Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Med Microbiol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Acikgoz, Ziya Cibali</creatorName>
      <givenName>Ziya Cibali</givenName>
      <familyName>Acikgoz</familyName>
      <affiliation>Yildirim Beyazit Univ, Fac Med, Dept Med Microbiol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Durmaz, Riza</creatorName>
      <givenName>Riza</givenName>
      <familyName>Durmaz</familyName>
      <affiliation>Yildirim Beyazit Univ, Fac Med, Dept Med Microbiol, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Molecular Characterization Of Carbapenem-Resistant Acinetobacter Baumannii Blood Culture Isolates From Three Hospitals In Turkey</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/233202</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.7883/yoken.JJID.2020.478</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">We aimed to investigate the clonal relationships, common sequence types, and carbapenemase genes in 177 non-repetitive blood culture isolates of Acinetobacter baumannii collected from patients at three university hospitals in Turkey in 2016. Molecular epidemiological characteristics of the isolates were examined using pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST) (Pasteur scheme-cpn60, fusA, gltA, pyrG, recA, rplB, and rpoB). Multiplex PCR was used to investigate the carbapenemase genes, including bla(OXA-23-like),bla(OXA-24-like), bla(OXA-48-like), bla(OXA-58-like), bla(IMP), bla(VIM) and bla(NDm). PFGE genotyping yielded 92 pulsotypes with a clustering ratio of 69.7%. As per a &amp;gt;= 85% similarity coefficient, 159 (90.9%) isolates were found to be clonally related. The bla(OXA-)(23-like) and bla(OXA-)(58)-like genes were identified in 100% and 28.2% of the isolates, respectively. The bla(NDM) gene was identified in two isolates. The MLST analysis included 54 isolates with different pulsotypes, and 29 sequence types (STs). Most of the isolates (n = 36) belonged to the clonal complex (CC)2, one isolate belonged to CC1, and one isolate belonged to CC164. Sixteen new STs (ST1235-ST1250) were identified. Identifying both global ST2 and a large number of new STs, revealed high genetic diversity in A. baumannii isolates in the study population.</description>
  </descriptions>
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