1 Ocak 1996 Dergi makalesi Açık Erişim

Mustafaev, M; Yucel, F; Cirakoglu, B; Bermek, E

JSON

{
  "conceptdoi": "10.81043/aperta.103800", 
  "conceptrecid": "103800", 
  "created": "2021-03-16T15:10:07.249778+00:00", 
  "doi": "10.81043/aperta.103801", 
  "files": [
    {
      "bucket": "40b8c2f6-9228-4bf5-a88c-d73eac4968b6", 
      "checksum": "md5:0e769098660881f60a5339b165939641", 
      "key": "bib-b0c483ca-73e6-4320-ad7d-c4f71b5568b0.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/40b8c2f6-9228-4bf5-a88c-d73eac4968b6/bib-b0c483ca-73e6-4320-ad7d-c4f71b5568b0.txt"
      }, 
      "size": 236, 
      "type": "txt"
    }
  ], 
  "id": 103801, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.81043/aperta.103801.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/40b8c2f6-9228-4bf5-a88c-d73eac4968b6", 
    "conceptbadge": "https://aperta.ulakbim.gov.tr/badge/doi/10.81043/aperta.103800.svg", 
    "conceptdoi": "https://doi.org/10.81043/aperta.103800", 
    "doi": "https://doi.org/10.81043/aperta.103801", 
    "html": "https://aperta.ulakbim.gov.tr/record/103801", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/103801", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/103801"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-adresli-yayinlar"
      }
    ], 
    "creators": [
      {
        "name": "Mustafaev, M"
      }, 
      {
        "name": "Yucel, F"
      }, 
      {
        "name": "Cirakoglu, B"
      }, 
      {
        "name": "Bermek, E"
      }
    ], 
    "description": "The immunogenic properties of water soluble (PAA-Cu2+-BSA) and colloidal (PAA-Cu2+-BSA.P) polycomplexes were investigated, and the specificity of antibodies produced was analyzed. Polycomplexes containing progesterone appeared to possess a high steroid-specific immunogenic activity. A comparative study of immunogenic properties of polycomplexes versus BSA.P + incomplete Freund's adjuvant (IFA) mixtures revealed differences in regards to the specificity of antibody production. In contrast to the IFA system, polycomplexes were able to generate P- as well as BSA-specific antibodies. Such a response is determined, possibly, by increases in the immunogenicity of weak antigenic determinants on the surface of protein globules and/or by the representation of 'dormant' determinants existing in the inner site upon complex formation with polyelectrolytes. Finally, using a short immunization procedure based on use of PAA-Cu2+-BSA polycomplexes, we produced seven monoclonal antibodies against progesterone included in polyelectrolyte complexes with affinities K-d ranging between 1.3 x 10(-7) and 9 x 10(-8) M.", 
    "doi": "10.81043/aperta.103801", 
    "has_grant": false, 
    "journal": {
      "issue": "2-3", 
      "pages": "63-68", 
      "title": "IMMUNOLOGY LETTERS", 
      "volume": "52"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "1996-01-01", 
    "related_identifiers": [
      {
        "identifier": "10.81043/aperta.103800", 
        "relation": "isVersionOf", 
        "scheme": "doi"
      }
    ], 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "103801"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "103800"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Immune response to progesterone involved in Cu2+-mediated polyanion-protein complex - Antigen specificity and affinity of hybridoma clones"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 4.0, 
    "unique_downloads": 4.0, 
    "unique_views": 19.0, 
    "version_downloads": 4.0, 
    "version_unique_downloads": 4.0, 
    "version_unique_views": 19.0, 
    "version_views": 20.0, 
    "version_volume": 944.0, 
    "views": 20.0, 
    "volume": 944.0
  }, 
  "updated": "2021-03-16T15:10:07.304360+00:00"
}