1 Ocak 2000 Dergi makalesi Açık Erişim

Basalp, A; Mustafaeva, Z; Mustafaev, M; Bermek, E

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{
  "@context": "https://schema.org/", 
  "@id": 95361, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Basalp, A"
    }, 
    {
      "@type": "Person", 
      "name": "Mustafaeva, Z"
    }, 
    {
      "@type": "Person", 
      "name": "Mustafaev, M"
    }, 
    {
      "@type": "Person", 
      "name": "Bermek, E"
    }
  ], 
  "datePublished": "2000-01-01", 
  "description": "The immunogenic properties of 17 beta -estradiol, immobilized in negatively charged polymer gels, were investigated, and the specificity of antibodies produced was analyzed. The polymer gels developed were composed of a hydrophobic estradiol core surrounded by hydrophilic polyanions as corona. As an immunogen, it was conceived to function via a dual mode, that is as a hapten-delivery system (prolongation effect) and as a polyelectrolyte adjuvant. Polymer gels containing estradiol appeared to possess a high estradiol-specific immunogenicity even without the addition of traditional adjuvants. A comparative study of estradiol trapped in polymer gels versus estradiol conjugated to bovine serum albumin (BSA.E) + Incomplete Freund's Adjuvant (IFA) mixtures revealed similar immunogenic properties in terms of induction of specific antibodies. Following a short immunization procedure based on the use of 17 beta -estradiol immobilized in polymer gels, we developed 10 specific monoclonal antibodies with K-d values ranging between 1.2 X 10(-7) and 8 X 10(-8) M.", 
  "headline": "Immune response to 17 beta-estradiol involved in polymer gels: Antigen specificity and affinity of hybridoma clones", 
  "identifier": 95361, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Immune response to 17 beta-estradiol involved in polymer gels: Antigen specificity and affinity of hybridoma clones", 
  "url": "https://aperta.ulakbim.gov.tr/record/95361"
}