1 Ocak 2020 Dergi makalesi Açık Erişim

Arslan, Dilek Betul; Gurvit, Hakan; Genc, Ozan; Kicik, Ani; Eryurek, Kardelen; Cengiz, Sevim; Erdogdu, Emel; Yildirim, Zerrin; Tufekcioglu, Zeynep; Ulug, Aziz Mufit; Bilgic, Basar; Hanagasi, Hasmet; Tuzun, Erdem; Demiralp, Tamer; Ozturk-Isik, Esin

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Arslan, Dilek Betul</dc:creator>
  <dc:creator>Gurvit, Hakan</dc:creator>
  <dc:creator>Genc, Ozan</dc:creator>
  <dc:creator>Kicik, Ani</dc:creator>
  <dc:creator>Eryurek, Kardelen</dc:creator>
  <dc:creator>Cengiz, Sevim</dc:creator>
  <dc:creator>Erdogdu, Emel</dc:creator>
  <dc:creator>Yildirim, Zerrin</dc:creator>
  <dc:creator>Tufekcioglu, Zeynep</dc:creator>
  <dc:creator>Ulug, Aziz Mufit</dc:creator>
  <dc:creator>Bilgic, Basar</dc:creator>
  <dc:creator>Hanagasi, Hasmet</dc:creator>
  <dc:creator>Tuzun, Erdem</dc:creator>
  <dc:creator>Demiralp, Tamer</dc:creator>
  <dc:creator>Ozturk-Isik, Esin</dc:creator>
  <dc:date>2020-01-01</dc:date>
  <dc:description>Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. The purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as "posterior hypoperfusion" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). The PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/9533</dc:identifier>
  <dc:identifier>oai:zenodo.org:9533</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF NEURAL TRANSMISSION 127(9) 1285-1294</dc:source>
  <dc:title>The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>