1 Ocak 2020 Dergi makalesi Açık Erişim

Arslan, Dilek Betul; Gurvit, Hakan; Genc, Ozan; Kicik, Ani; Eryurek, Kardelen; Cengiz, Sevim; Erdogdu, Emel; Yildirim, Zerrin; Tufekcioglu, Zeynep; Ulug, Aziz Mufit; Bilgic, Basar; Hanagasi, Hasmet; Tuzun, Erdem; Demiralp, Tamer; Ozturk-Isik, Esin

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    "creators": [
      {
        "affiliation": "Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey", 
        "name": "Arslan, Dilek Betul"
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
        "name": "Gurvit, Hakan"
      }, 
      {
        "affiliation": "Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey", 
        "name": "Genc, Ozan"
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      {
        "name": "Kicik, Ani"
      }, 
      {
        "affiliation": "Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Neurosci, Istanbul, Turkey", 
        "name": "Eryurek, Kardelen"
      }, 
      {
        "affiliation": "Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey", 
        "name": "Cengiz, Sevim"
      }, 
      {
        "name": "Erdogdu, Emel"
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
        "name": "Yildirim, Zerrin"
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
        "name": "Tufekcioglu, Zeynep"
      }, 
      {
        "name": "Ulug, Aziz Mufit"
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
        "name": "Bilgic, Basar"
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
        "name": "Hanagasi, Hasmet"
      }, 
      {
        "affiliation": "Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Neurosci, Istanbul, Turkey", 
        "name": "Tuzun, Erdem"
      }, 
      {
        "name": "Demiralp, Tamer"
      }, 
      {
        "affiliation": "Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey", 
        "name": "Ozturk-Isik, Esin"
      }
    ], 
    "description": "Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. The purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as \"posterior hypoperfusion\" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). The PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD.", 
    "doi": "10.1007/s00702-020-02227-6", 
    "has_grant": false, 
    "journal": {
      "issue": "9", 
      "pages": "1285-1294", 
      "title": "JOURNAL OF NEURAL TRANSMISSION", 
      "volume": "127"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2020-01-01", 
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    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
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    "title": "The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI"
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