1 Ocak 2020 Dergi makalesi Açık Erişim

Arslan, Dilek Betul; Gurvit, Hakan; Genc, Ozan; Kicik, Ani; Eryurek, Kardelen; Cengiz, Sevim; Erdogdu, Emel; Yildirim, Zerrin; Tufekcioglu, Zeynep; Ulug, Aziz Mufit; Bilgic, Basar; Hanagasi, Hasmet; Tuzun, Erdem; Demiralp, Tamer; Ozturk-Isik, Esin

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/9533</identifier>
  <creators>
    <creator>
      <creatorName>Arslan, Dilek Betul</creatorName>
      <givenName>Dilek Betul</givenName>
      <familyName>Arslan</familyName>
      <affiliation>Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gurvit, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Gurvit</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol &amp; Movement Disorders Unit, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Genc, Ozan</creatorName>
      <givenName>Ozan</givenName>
      <familyName>Genc</familyName>
      <affiliation>Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kicik, Ani</creatorName>
      <givenName>Ani</givenName>
      <familyName>Kicik</familyName>
    </creator>
    <creator>
      <creatorName>Eryurek, Kardelen</creatorName>
      <givenName>Kardelen</givenName>
      <familyName>Eryurek</familyName>
      <affiliation>Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Neurosci, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cengiz, Sevim</creatorName>
      <givenName>Sevim</givenName>
      <familyName>Cengiz</familyName>
      <affiliation>Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erdogdu, Emel</creatorName>
      <givenName>Emel</givenName>
      <familyName>Erdogdu</familyName>
    </creator>
    <creator>
      <creatorName>Yildirim, Zerrin</creatorName>
      <givenName>Zerrin</givenName>
      <familyName>Yildirim</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol &amp; Movement Disorders Unit, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tufekcioglu, Zeynep</creatorName>
      <givenName>Zeynep</givenName>
      <familyName>Tufekcioglu</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol &amp; Movement Disorders Unit, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ulug, Aziz Mufit</creatorName>
      <givenName>Aziz Mufit</givenName>
      <familyName>Ulug</familyName>
    </creator>
    <creator>
      <creatorName>Bilgic, Basar</creatorName>
      <givenName>Basar</givenName>
      <familyName>Bilgic</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol &amp; Movement Disorders Unit, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hanagasi, Hasmet</creatorName>
      <givenName>Hasmet</givenName>
      <familyName>Hanagasi</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol &amp; Movement Disorders Unit, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tuzun, Erdem</creatorName>
      <givenName>Erdem</givenName>
      <familyName>Tuzun</familyName>
      <affiliation>Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Neurosci, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demiralp, Tamer</creatorName>
      <givenName>Tamer</givenName>
      <familyName>Demiralp</familyName>
    </creator>
    <creator>
      <creatorName>Ozturk-Isik, Esin</creatorName>
      <givenName>Esin</givenName>
      <familyName>Ozturk-Isik</familyName>
      <affiliation>Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Cerebral Blood Flow Deficits In Parkinson'S Disease With Mild Cognitive Impairment Using Arterial Spin Labeling Mri</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/9533</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s00702-020-02227-6</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. The purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as "posterior hypoperfusion" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). The PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD.</description>
  </descriptions>
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