1 Ocak 2020 Dergi makalesi Açık Erişim

Arslan, Dilek Betul; Gurvit, Hakan; Genc, Ozan; Kicik, Ani; Eryurek, Kardelen; Cengiz, Sevim; Erdogdu, Emel; Yildirim, Zerrin; Tufekcioglu, Zeynep; Ulug, Aziz Mufit; Bilgic, Basar; Hanagasi, Hasmet; Tuzun, Erdem; Demiralp, Tamer; Ozturk-Isik, Esin

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  "@context": "https://schema.org/", 
  "@id": 9533, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey", 
      "name": "Arslan, Dilek Betul"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
      "name": "Gurvit, Hakan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey", 
      "name": "Genc, Ozan"
    }, 
    {
      "@type": "Person", 
      "name": "Kicik, Ani"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Neurosci, Istanbul, Turkey", 
      "name": "Eryurek, Kardelen"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey", 
      "name": "Cengiz, Sevim"
    }, 
    {
      "@type": "Person", 
      "name": "Erdogdu, Emel"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
      "name": "Yildirim, Zerrin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
      "name": "Tufekcioglu, Zeynep"
    }, 
    {
      "@type": "Person", 
      "name": "Ulug, Aziz Mufit"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
      "name": "Bilgic, Basar"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey", 
      "name": "Hanagasi, Hasmet"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Neurosci, Istanbul, Turkey", 
      "name": "Tuzun, Erdem"
    }, 
    {
      "@type": "Person", 
      "name": "Demiralp, Tamer"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey", 
      "name": "Ozturk-Isik, Esin"
    }
  ], 
  "datePublished": "2020-01-01", 
  "description": "Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. The purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as \"posterior hypoperfusion\" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). The PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD.", 
  "headline": "The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI", 
  "identifier": 9533, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI", 
  "url": "https://aperta.ulakbim.gov.tr/record/9533"
}