1 Ocak 2020 Dergi makalesi Açık Erişim

Arslan, Dilek Betul; Gurvit, Hakan; Genc, Ozan; Kicik, Ani; Eryurek, Kardelen; Cengiz, Sevim; Erdogdu, Emel; Yildirim, Zerrin; Tufekcioglu, Zeynep; Ulug, Aziz Mufit; Bilgic, Basar; Hanagasi, Hasmet; Tuzun, Erdem; Demiralp, Tamer; Ozturk-Isik, Esin

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{
  "DOI": "10.1007/s00702-020-02227-6", 
  "abstract": "Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. The purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. ASL-MRI data were acquired by signal targeting with alternating radio-frequency labeling with Look-Locker sequence at 3 T. Single nucleotide polymorphism genotyping for rs9468 [microtubule-associated protein tau (MAPT) H1/H1 versus H1/H2 haplotype] was performed using a Stratagene Mx3005p real-time polymerase chain-reaction system (Agilent Technologies, USA). There were 15 subjects withMAPTH1/H1 and 11 subjects withMAPTH1/H2 within PD-MCI, and 33 subjects withMAPTH1/H1 and 19 subjects withMAPTH1/H2 within all PD. Voxel-wise differences of cerebral blood flow (CBF) values between HC, PD-CN and PD-MCI were assessed by one-way analysis of variance followed by pairwise post hoc comparisons. Further, the subgroup of PD patients carrying the riskyMAPTH1/H1 haplotype was compared with noncarriers (MAPTH1/H2 haplotype) in terms of CBF by a two-samplettest. A pattern that could be summarized as \"posterior hypoperfusion\" (PH) differentiated the PD-MCI group from the HC group with an accuracy of 92.6% (sensitivity = 93%, specificity = 93%). Additionally, the PD patients withMAPTH1/H1 haplotype had decreased perfusion than the ones with H1/H2 haplotype at the posterior areas of the visual network (VN), default mode network (DMN), and dorsal attention network (DAN). The PH-type pattern in ASL-MRI could be employed as a biomarker of both current cognitive impairment and future cognitive decline in PD.", 
  "author": [
    {
      "family": "Arslan", 
      "given": " Dilek Betul"
    }, 
    {
      "family": "Gurvit", 
      "given": " Hakan"
    }, 
    {
      "family": "Genc", 
      "given": " Ozan"
    }, 
    {
      "family": "Kicik", 
      "given": " Ani"
    }, 
    {
      "family": "Eryurek", 
      "given": " Kardelen"
    }, 
    {
      "family": "Cengiz", 
      "given": " Sevim"
    }, 
    {
      "family": "Erdogdu", 
      "given": " Emel"
    }, 
    {
      "family": "Yildirim", 
      "given": " Zerrin"
    }, 
    {
      "family": "Tufekcioglu", 
      "given": " Zeynep"
    }, 
    {
      "family": "Ulug", 
      "given": " Aziz Mufit"
    }, 
    {
      "family": "Bilgic", 
      "given": " Basar"
    }, 
    {
      "family": "Hanagasi", 
      "given": " Hasmet"
    }, 
    {
      "family": "Tuzun", 
      "given": " Erdem"
    }, 
    {
      "family": "Demiralp", 
      "given": " Tamer"
    }, 
    {
      "family": "Ozturk-Isik", 
      "given": " Esin"
    }
  ], 
  "container_title": "JOURNAL OF NEURAL TRANSMISSION", 
  "id": "9533", 
  "issue": "9", 
  "issued": {
    "date-parts": [
      [
        2020, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1285-1294", 
  "title": "The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI", 
  "type": "article-journal", 
  "volume": "127"
}