1 Ocak 2018 Dergi makalesi Açık Erişim

Narter, Fehmi; Diren, Ayca; Kafkasli, Alper; Eronat, Allison P.; Seyhan, M. Fatih; Yilmaz-Aydogan, Hulya; Sarikaya, Sukran; Hatipoglu, Seda Damla; Sarica, Kemal; Ozturk, Oguz

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{
  "DOI": "10.25135/rnp.48.17.11.075", 
  "abstract": "One of the many properties of propolis, a gift of nature, is that it is a potent antioxidant agent, which has been shown to be a miracle-worker in many different diseases. In this study, its possible protective and reversing effects against hiperoxaluria was investigated in a rat model in comparison with verapamil In all 5 groups (Total n=76), aside from the control, hiperoxaluria was induced with continuous ethylene glycol (EG) administration. The others received EG only, 50 mg/kg propolis, 100 mg/kg propolis and 1 mg/kg verapamil To estimate the antioxidant/oxidant status in the tissue and serum samples, catalase (CAT), superoxide dismutase (SOD), total glutathione (GSH), nitric oxide (NO), malonyl dialdehyde (MDA) and total anti-oxidant capacity (T-AOC) were measured after 7 and 28 days. In the early phase, serum T-AOC levels were significantly elevated in the EG+P100 (p=0.0062) compared to the control, while in the late phase, it was elevated in the EG+P50 (p=0.037) and EG+V (p=0.009) compared to the EG only group. Propolis administration was observed to dramatically decrease crystal deposition (p<0.0001) and was more effective in the prevention of oxalate-induced renal injury than verapamil Propolis being a natural product with almost none adverse effects elevates its value as a future approach to urolithiasis.", 
  "author": [
    {
      "family": "Narter", 
      "given": " Fehmi"
    }, 
    {
      "family": "Diren", 
      "given": " Ayca"
    }, 
    {
      "family": "Kafkasli", 
      "given": " Alper"
    }, 
    {
      "family": "Eronat", 
      "given": " Allison P."
    }, 
    {
      "family": "Seyhan", 
      "given": " M. Fatih"
    }, 
    {
      "family": "Yilmaz-Aydogan", 
      "given": " Hulya"
    }, 
    {
      "family": "Sarikaya", 
      "given": " Sukran"
    }, 
    {
      "family": "Hatipoglu", 
      "given": " Seda Damla"
    }, 
    {
      "family": "Sarica", 
      "given": " Kemal"
    }, 
    {
      "family": "Ozturk", 
      "given": " Oguz"
    }
  ], 
  "container_title": "RECORDS OF NATURAL PRODUCTS", 
  "id": "93359", 
  "issue": "5", 
  "issued": {
    "date-parts": [
      [
        2018, 
        1, 
        1
      ]
    ]
  }, 
  "page": "445-459", 
  "title": "Anatolian Propolis Prevents Oxalate Kidney Stones: Dramatic Reduction of Crystal Deposition in Ethylene-Glycol-Induced Rat Model", 
  "type": "article-journal", 
  "volume": "12"
}