1 Ocak 2019 Dergi makalesi Açık Erişim

Bal-Ozturk, Ayca; Karal-Yilmaz, Oksan; Akguner, Zeynep Puren; Aksu, Soner; Tas, Arzu; Olmez, Hulya

Dublin Core

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  <dc:creator>Bal-Ozturk, Ayca</dc:creator>
  <dc:creator>Karal-Yilmaz, Oksan</dc:creator>
  <dc:creator>Akguner, Zeynep Puren</dc:creator>
  <dc:creator>Aksu, Soner</dc:creator>
  <dc:creator>Tas, Arzu</dc:creator>
  <dc:creator>Olmez, Hulya</dc:creator>
  <dc:date>2019-01-01</dc:date>
  <dc:description>In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (&lt;100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze-drying technique. Genipin was used as a crosslinker. The prepared chitosan-based sponges were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy-energy-dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge-like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like-nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/90739</dc:identifier>
  <dc:identifier>oai:zenodo.org:90739</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF APPLIED POLYMER SCIENCE 136(19)</dc:source>
  <dc:title>Sponge-like chitosan-based nanostructured antibacterial material as a topical hemostat</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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