1 Ocak 2019 Dergi makalesi Açık Erişim

Bal-Ozturk, Ayca; Karal-Yilmaz, Oksan; Akguner, Zeynep Puren; Aksu, Soner; Tas, Arzu; Olmez, Hulya

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/90739</identifier>
  <creators>
    <creator>
      <creatorName>Bal-Ozturk, Ayca</creatorName>
      <givenName>Ayca</givenName>
      <familyName>Bal-Ozturk</familyName>
    </creator>
    <creator>
      <creatorName>Karal-Yilmaz, Oksan</creatorName>
      <givenName>Oksan</givenName>
      <familyName>Karal-Yilmaz</familyName>
      <affiliation>TUBITAK Marmara Res Ctr, Genet Engn &amp; Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akguner, Zeynep Puren</creatorName>
      <givenName>Zeynep Puren</givenName>
      <familyName>Akguner</familyName>
      <affiliation>Istinye Univ, Inst Hlth Sci, Dept Stem Cell &amp; Tissue Engn, TR-34010 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aksu, Soner</creatorName>
      <givenName>Soner</givenName>
      <familyName>Aksu</familyName>
      <affiliation>TUBITAK Marmara Res Ctr, Genet Engn &amp; Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tas, Arzu</creatorName>
      <givenName>Arzu</givenName>
      <familyName>Tas</familyName>
      <affiliation>TUBITAK Marmara Res Ctr, Genet Engn &amp; Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Olmez, Hulya</creatorName>
      <givenName>Hulya</givenName>
      <familyName>Olmez</familyName>
      <affiliation>TUBITAK Marmara Res Ctr, Mat Inst, TR-41470 Gebze, Kocaeli, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Sponge-Like Chitosan-Based Nanostructured Antibacterial Material As A Topical Hemostat</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/90739</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/app.47522</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (&amp;lt;100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze-drying technique. Genipin was used as a crosslinker. The prepared chitosan-based sponges were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy-energy-dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge-like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like-nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.</description>
  </descriptions>
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