1 Ocak 2019 Dergi makalesi Açık Erişim

Bal-Ozturk, Ayca; Karal-Yilmaz, Oksan; Akguner, Zeynep Puren; Aksu, Soner; Tas, Arzu; Olmez, Hulya

JSON

{
  "conceptrecid": "90738", 
  "created": "2021-03-16T11:56:55.693153+00:00", 
  "doi": "10.1002/app.47522", 
  "files": [
    {
      "bucket": "0126e12f-0093-4b59-bcfa-3a86ff5bed19", 
      "checksum": "md5:db7e70a6c1a2f80151506b2464df5e15", 
      "key": "bib-e1bf100e-e795-4778-af4e-c99cfcedf128.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/0126e12f-0093-4b59-bcfa-3a86ff5bed19/bib-e1bf100e-e795-4778-af4e-c99cfcedf128.txt"
      }, 
      "size": 217, 
      "type": "txt"
    }
  ], 
  "id": 90739, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1002/app.47522.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/0126e12f-0093-4b59-bcfa-3a86ff5bed19", 
    "doi": "https://doi.org/10.1002/app.47522", 
    "html": "https://aperta.ulakbim.gov.tr/record/90739", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/90739", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/90739"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-adresli-yayinlar"
      }, 
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "name": "Bal-Ozturk, Ayca"
      }, 
      {
        "affiliation": "TUBITAK Marmara Res Ctr, Genet Engn & Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey", 
        "name": "Karal-Yilmaz, Oksan"
      }, 
      {
        "affiliation": "Istinye Univ, Inst Hlth Sci, Dept Stem Cell & Tissue Engn, TR-34010 Istanbul, Turkey", 
        "name": "Akguner, Zeynep Puren"
      }, 
      {
        "affiliation": "TUBITAK Marmara Res Ctr, Genet Engn & Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey", 
        "name": "Aksu, Soner"
      }, 
      {
        "affiliation": "TUBITAK Marmara Res Ctr, Genet Engn & Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey", 
        "name": "Tas, Arzu"
      }, 
      {
        "affiliation": "TUBITAK Marmara Res Ctr, Mat Inst, TR-41470 Gebze, Kocaeli, Turkey", 
        "name": "Olmez, Hulya"
      }
    ], 
    "description": "In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (<100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze-drying technique. Genipin was used as a crosslinker. The prepared chitosan-based sponges were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy-energy-dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge-like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like-nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.", 
    "doi": "10.1002/app.47522", 
    "has_grant": false, 
    "journal": {
      "issue": "19", 
      "title": "JOURNAL OF APPLIED POLYMER SCIENCE", 
      "volume": "136"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2019-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "90739"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "90738"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Sponge-like chitosan-based nanostructured antibacterial material as a topical hemostat"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 10.0, 
    "unique_downloads": 10.0, 
    "unique_views": 62.0, 
    "version_downloads": 10.0, 
    "version_unique_downloads": 10.0, 
    "version_unique_views": 62.0, 
    "version_views": 65.0, 
    "version_volume": 2170.0, 
    "views": 65.0, 
    "volume": 2170.0
  }, 
  "updated": "2021-03-16T11:56:55.742510+00:00"
}