1 Ocak 2019 Dergi makalesi Açık Erişim

Bal-Ozturk, Ayca; Karal-Yilmaz, Oksan; Akguner, Zeynep Puren; Aksu, Soner; Tas, Arzu; Olmez, Hulya

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{
  "DOI": "10.1002/app.47522", 
  "abstract": "In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (<100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze-drying technique. Genipin was used as a crosslinker. The prepared chitosan-based sponges were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy-energy-dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge-like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like-nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.", 
  "author": [
    {
      "family": "Bal-Ozturk", 
      "given": " Ayca"
    }, 
    {
      "family": "Karal-Yilmaz", 
      "given": " Oksan"
    }, 
    {
      "family": "Akguner", 
      "given": " Zeynep Puren"
    }, 
    {
      "family": "Aksu", 
      "given": " Soner"
    }, 
    {
      "family": "Tas", 
      "given": " Arzu"
    }, 
    {
      "family": "Olmez", 
      "given": " Hulya"
    }
  ], 
  "container_title": "JOURNAL OF APPLIED POLYMER SCIENCE", 
  "id": "90739", 
  "issue": "19", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Sponge-like chitosan-based nanostructured antibacterial material as a topical hemostat", 
  "type": "article-journal", 
  "volume": "136"
}