1 Ocak 2019 Dergi makalesi Açık Erişim

Bal-Ozturk, Ayca; Karal-Yilmaz, Oksan; Akguner, Zeynep Puren; Aksu, Soner; Tas, Arzu; Olmez, Hulya

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{
  "@context": "https://schema.org/", 
  "@id": 90739, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Bal-Ozturk, Ayca"
    }, 
    {
      "@type": "Person", 
      "affiliation": "TUBITAK Marmara Res Ctr, Genet Engn & Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey", 
      "name": "Karal-Yilmaz, Oksan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istinye Univ, Inst Hlth Sci, Dept Stem Cell & Tissue Engn, TR-34010 Istanbul, Turkey", 
      "name": "Akguner, Zeynep Puren"
    }, 
    {
      "@type": "Person", 
      "affiliation": "TUBITAK Marmara Res Ctr, Genet Engn & Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey", 
      "name": "Aksu, Soner"
    }, 
    {
      "@type": "Person", 
      "affiliation": "TUBITAK Marmara Res Ctr, Genet Engn & Biotechnol Inst, TR-41470 Gebze, Kocaeli, Turkey", 
      "name": "Tas, Arzu"
    }, 
    {
      "@type": "Person", 
      "affiliation": "TUBITAK Marmara Res Ctr, Mat Inst, TR-41470 Gebze, Kocaeli, Turkey", 
      "name": "Olmez, Hulya"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (<100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze-drying technique. Genipin was used as a crosslinker. The prepared chitosan-based sponges were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy-energy-dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge-like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like-nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.", 
  "headline": "Sponge-like chitosan-based nanostructured antibacterial material as a topical hemostat", 
  "identifier": 90739, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Sponge-like chitosan-based nanostructured antibacterial material as a topical hemostat", 
  "url": "https://aperta.ulakbim.gov.tr/record/90739"
}