1 Ocak 2019 Dergi makalesi Açık Erişim

Oz, Umut Can; Kucukturkmen, Berrin; Ozkose, Umut Ugur; Gulyuz, Sevgi; Bolat, Zeynep Busra; Telci, Dilek; Sahin, Fikrettin; Yilmaz, Ozgur; Bozkir, Asuman

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Oz, Umut Can</dc:creator>
  <dc:creator>Kucukturkmen, Berrin</dc:creator>
  <dc:creator>Ozkose, Umut Ugur</dc:creator>
  <dc:creator>Gulyuz, Sevgi</dc:creator>
  <dc:creator>Bolat, Zeynep Busra</dc:creator>
  <dc:creator>Telci, Dilek</dc:creator>
  <dc:creator>Sahin, Fikrettin</dc:creator>
  <dc:creator>Yilmaz, Ozgur</dc:creator>
  <dc:creator>Bozkir, Asuman</dc:creator>
  <dc:date>2019-01-01</dc:date>
  <dc:description>Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) range, which is one of the most recognized factors that governs the self-assembly of amphiphilic copolymers, for the first time. The findings indicate that PEtOx-b-PLA copolymers, containing PEtOx fractions of varied lengths, self-assemble to form polymersomes in the range of 98.35 to 119.50 nm. The encapsulation potential of PEtOx-b-PLA polymersomes was demonstrated by loading of docetaxel (hydrophobic) with 17.90% encapsulation efficiency and by loading of pDNA (hydrophilic) with 65.03% encapsulation efficiency. In addition, size distribution profiles showed that polymersomes are colloidally stable for 24 h at 37 degrees C and for 3 months at +4 degrees C. The cell viability results showed that PEtOx-b-PLA copolymer and polymersomes are not cytotoxic to HUVEC, HEK293 and hMSC cell lines.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/90691</dc:identifier>
  <dc:identifier>oai:zenodo.org:90691</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>CHEMNANOMAT 5(6) 766-775</dc:source>
  <dc:title>Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>