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Oz, Umut Can; Kucukturkmen, Berrin; Ozkose, Umut Ugur; Gulyuz, Sevgi; Bolat, Zeynep Busra; Telci, Dilek; Sahin, Fikrettin; Yilmaz, Ozgur; Bozkir, Asuman
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/90691</identifier> <creators> <creator> <creatorName>Oz, Umut Can</creatorName> <givenName>Umut Can</givenName> <familyName>Oz</familyName> <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation> </creator> <creator> <creatorName>Kucukturkmen, Berrin</creatorName> <givenName>Berrin</givenName> <familyName>Kucukturkmen</familyName> <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation> </creator> <creator> <creatorName>Ozkose, Umut Ugur</creatorName> <givenName>Umut Ugur</givenName> <familyName>Ozkose</familyName> </creator> <creator> <creatorName>Gulyuz, Sevgi</creatorName> <givenName>Sevgi</givenName> <familyName>Gulyuz</familyName> </creator> <creator> <creatorName>Bolat, Zeynep Busra</creatorName> <givenName>Zeynep Busra</givenName> <familyName>Bolat</familyName> <affiliation>Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Telci, Dilek</creatorName> <givenName>Dilek</givenName> <familyName>Telci</familyName> <affiliation>Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Sahin, Fikrettin</creatorName> <givenName>Fikrettin</givenName> <familyName>Sahin</familyName> <affiliation>Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Yilmaz, Ozgur</creatorName> <givenName>Ozgur</givenName> <familyName>Yilmaz</familyName> <affiliation>TUBITAK, Marmara Res Ctr, Mat Inst, Gebze, Turkey</affiliation> </creator> <creator> <creatorName>Bozkir, Asuman</creatorName> <givenName>Asuman</givenName> <familyName>Bozkir</familyName> <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation> </creator> </creators> <titles> <title>Design Of Colloidally Stable And Non-Toxic Petox-Based Polymersomes For Cargo Molecule Encapsulation</title> </titles> <publisher>Aperta</publisher> <publicationYear>2019</publicationYear> <dates> <date dateType="Issued">2019-01-01</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/90691</alternateIdentifier> </alternateIdentifiers> <relatedIdentifiers> <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/cnma.201800606</relatedIdentifier> </relatedIdentifiers> <rightsList> <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract">Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) range, which is one of the most recognized factors that governs the self-assembly of amphiphilic copolymers, for the first time. The findings indicate that PEtOx-b-PLA copolymers, containing PEtOx fractions of varied lengths, self-assemble to form polymersomes in the range of 98.35 to 119.50 nm. The encapsulation potential of PEtOx-b-PLA polymersomes was demonstrated by loading of docetaxel (hydrophobic) with 17.90% encapsulation efficiency and by loading of pDNA (hydrophilic) with 65.03% encapsulation efficiency. In addition, size distribution profiles showed that polymersomes are colloidally stable for 24 h at 37 degrees C and for 3 months at +4 degrees C. The cell viability results showed that PEtOx-b-PLA copolymer and polymersomes are not cytotoxic to HUVEC, HEK293 and hMSC cell lines.</description> </descriptions> </resource>
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