1 Ocak 2019 Dergi makalesi Açık Erişim

Oz, Umut Can; Kucukturkmen, Berrin; Ozkose, Umut Ugur; Gulyuz, Sevgi; Bolat, Zeynep Busra; Telci, Dilek; Sahin, Fikrettin; Yilmaz, Ozgur; Bozkir, Asuman

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/90691</identifier>
  <creators>
    <creator>
      <creatorName>Oz, Umut Can</creatorName>
      <givenName>Umut Can</givenName>
      <familyName>Oz</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kucukturkmen, Berrin</creatorName>
      <givenName>Berrin</givenName>
      <familyName>Kucukturkmen</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozkose, Umut Ugur</creatorName>
      <givenName>Umut Ugur</givenName>
      <familyName>Ozkose</familyName>
    </creator>
    <creator>
      <creatorName>Gulyuz, Sevgi</creatorName>
      <givenName>Sevgi</givenName>
      <familyName>Gulyuz</familyName>
    </creator>
    <creator>
      <creatorName>Bolat, Zeynep Busra</creatorName>
      <givenName>Zeynep Busra</givenName>
      <familyName>Bolat</familyName>
      <affiliation>Yeditepe Univ, Fac Engn, Dept Genet &amp; Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Telci, Dilek</creatorName>
      <givenName>Dilek</givenName>
      <familyName>Telci</familyName>
      <affiliation>Yeditepe Univ, Fac Engn, Dept Genet &amp; Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sahin, Fikrettin</creatorName>
      <givenName>Fikrettin</givenName>
      <familyName>Sahin</familyName>
      <affiliation>Yeditepe Univ, Fac Engn, Dept Genet &amp; Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yilmaz, Ozgur</creatorName>
      <givenName>Ozgur</givenName>
      <familyName>Yilmaz</familyName>
      <affiliation>TUBITAK, Marmara Res Ctr, Mat Inst, Gebze, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bozkir, Asuman</creatorName>
      <givenName>Asuman</givenName>
      <familyName>Bozkir</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Design Of Colloidally Stable And Non-Toxic Petox-Based Polymersomes For Cargo Molecule Encapsulation</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/90691</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/cnma.201800606</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) range, which is one of the most recognized factors that governs the self-assembly of amphiphilic copolymers, for the first time. The findings indicate that PEtOx-b-PLA copolymers, containing PEtOx fractions of varied lengths, self-assemble to form polymersomes in the range of 98.35 to 119.50 nm. The encapsulation potential of PEtOx-b-PLA polymersomes was demonstrated by loading of docetaxel (hydrophobic) with 17.90% encapsulation efficiency and by loading of pDNA (hydrophilic) with 65.03% encapsulation efficiency. In addition, size distribution profiles showed that polymersomes are colloidally stable for 24 h at 37 degrees C and for 3 months at +4 degrees C. The cell viability results showed that PEtOx-b-PLA copolymer and polymersomes are not cytotoxic to HUVEC, HEK293 and hMSC cell lines.</description>
  </descriptions>
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