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Oz, Umut Can; Kucukturkmen, Berrin; Ozkose, Umut Ugur; Gulyuz, Sevgi; Bolat, Zeynep Busra; Telci, Dilek; Sahin, Fikrettin; Yilmaz, Ozgur; Bozkir, Asuman
{ "DOI": "10.1002/cnma.201800606", "abstract": "Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) range, which is one of the most recognized factors that governs the self-assembly of amphiphilic copolymers, for the first time. The findings indicate that PEtOx-b-PLA copolymers, containing PEtOx fractions of varied lengths, self-assemble to form polymersomes in the range of 98.35 to 119.50 nm. The encapsulation potential of PEtOx-b-PLA polymersomes was demonstrated by loading of docetaxel (hydrophobic) with 17.90% encapsulation efficiency and by loading of pDNA (hydrophilic) with 65.03% encapsulation efficiency. In addition, size distribution profiles showed that polymersomes are colloidally stable for 24 h at 37 degrees C and for 3 months at +4 degrees C. The cell viability results showed that PEtOx-b-PLA copolymer and polymersomes are not cytotoxic to HUVEC, HEK293 and hMSC cell lines.", "author": [ { "family": "Oz", "given": " Umut Can" }, { "family": "Kucukturkmen", "given": " Berrin" }, { "family": "Ozkose", "given": " Umut Ugur" }, { "family": "Gulyuz", "given": " Sevgi" }, { "family": "Bolat", "given": " Zeynep Busra" }, { "family": "Telci", "given": " Dilek" }, { "family": "Sahin", "given": " Fikrettin" }, { "family": "Yilmaz", "given": " Ozgur" }, { "family": "Bozkir", "given": " Asuman" } ], "container_title": "CHEMNANOMAT", "id": "90691", "issue": "6", "issued": { "date-parts": [ [ 2019, 1, 1 ] ] }, "page": "766-775", "title": "Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation", "type": "article-journal", "volume": "5" }
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