1 Ocak 2019 Dergi makalesi Açık Erişim

Oz, Umut Can; Kucukturkmen, Berrin; Ozkose, Umut Ugur; Gulyuz, Sevgi; Bolat, Zeynep Busra; Telci, Dilek; Sahin, Fikrettin; Yilmaz, Ozgur; Bozkir, Asuman

Citation Style Language JSON

{
  "DOI": "10.1002/cnma.201800606", 
  "abstract": "Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) range, which is one of the most recognized factors that governs the self-assembly of amphiphilic copolymers, for the first time. The findings indicate that PEtOx-b-PLA copolymers, containing PEtOx fractions of varied lengths, self-assemble to form polymersomes in the range of 98.35 to 119.50 nm. The encapsulation potential of PEtOx-b-PLA polymersomes was demonstrated by loading of docetaxel (hydrophobic) with 17.90% encapsulation efficiency and by loading of pDNA (hydrophilic) with 65.03% encapsulation efficiency. In addition, size distribution profiles showed that polymersomes are colloidally stable for 24 h at 37 degrees C and for 3 months at +4 degrees C. The cell viability results showed that PEtOx-b-PLA copolymer and polymersomes are not cytotoxic to HUVEC, HEK293 and hMSC cell lines.", 
  "author": [
    {
      "family": "Oz", 
      "given": " Umut Can"
    }, 
    {
      "family": "Kucukturkmen", 
      "given": " Berrin"
    }, 
    {
      "family": "Ozkose", 
      "given": " Umut Ugur"
    }, 
    {
      "family": "Gulyuz", 
      "given": " Sevgi"
    }, 
    {
      "family": "Bolat", 
      "given": " Zeynep Busra"
    }, 
    {
      "family": "Telci", 
      "given": " Dilek"
    }, 
    {
      "family": "Sahin", 
      "given": " Fikrettin"
    }, 
    {
      "family": "Yilmaz", 
      "given": " Ozgur"
    }, 
    {
      "family": "Bozkir", 
      "given": " Asuman"
    }
  ], 
  "container_title": "CHEMNANOMAT", 
  "id": "90691", 
  "issue": "6", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "766-775", 
  "title": "Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation", 
  "type": "article-journal", 
  "volume": "5"
}