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Oz, Umut Can; Kucukturkmen, Berrin; Ozkose, Umut Ugur; Gulyuz, Sevgi; Bolat, Zeynep Busra; Telci, Dilek; Sahin, Fikrettin; Yilmaz, Ozgur; Bozkir, Asuman
{ "@context": "https://schema.org/", "@id": 90691, "@type": "ScholarlyArticle", "creator": [ { "@type": "Person", "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey", "name": "Oz, Umut Can" }, { "@type": "Person", "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey", "name": "Kucukturkmen, Berrin" }, { "@type": "Person", "name": "Ozkose, Umut Ugur" }, { "@type": "Person", "name": "Gulyuz, Sevgi" }, { "@type": "Person", "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey", "name": "Bolat, Zeynep Busra" }, { "@type": "Person", "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey", "name": "Telci, Dilek" }, { "@type": "Person", "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey", "name": "Sahin, Fikrettin" }, { "@type": "Person", "affiliation": "TUBITAK, Marmara Res Ctr, Mat Inst, Gebze, Turkey", "name": "Yilmaz, Ozgur" }, { "@type": "Person", "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey", "name": "Bozkir, Asuman" } ], "datePublished": "2019-01-01", "description": "Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) range, which is one of the most recognized factors that governs the self-assembly of amphiphilic copolymers, for the first time. The findings indicate that PEtOx-b-PLA copolymers, containing PEtOx fractions of varied lengths, self-assemble to form polymersomes in the range of 98.35 to 119.50 nm. The encapsulation potential of PEtOx-b-PLA polymersomes was demonstrated by loading of docetaxel (hydrophobic) with 17.90% encapsulation efficiency and by loading of pDNA (hydrophilic) with 65.03% encapsulation efficiency. In addition, size distribution profiles showed that polymersomes are colloidally stable for 24 h at 37 degrees C and for 3 months at +4 degrees C. The cell viability results showed that PEtOx-b-PLA copolymer and polymersomes are not cytotoxic to HUVEC, HEK293 and hMSC cell lines.", "headline": "Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation", "identifier": 90691, "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", "license": "http://www.opendefinition.org/licenses/cc-by", "name": "Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation", "url": "https://aperta.ulakbim.gov.tr/record/90691" }
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