1 Ocak 2019 Dergi makalesi Açık Erişim

Oz, Umut Can; Kucukturkmen, Berrin; Ozkose, Umut Ugur; Gulyuz, Sevgi; Bolat, Zeynep Busra; Telci, Dilek; Sahin, Fikrettin; Yilmaz, Ozgur; Bozkir, Asuman

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{
  "@context": "https://schema.org/", 
  "@id": 90691, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey", 
      "name": "Oz, Umut Can"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey", 
      "name": "Kucukturkmen, Berrin"
    }, 
    {
      "@type": "Person", 
      "name": "Ozkose, Umut Ugur"
    }, 
    {
      "@type": "Person", 
      "name": "Gulyuz, Sevgi"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey", 
      "name": "Bolat, Zeynep Busra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey", 
      "name": "Telci, Dilek"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey", 
      "name": "Sahin, Fikrettin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "TUBITAK, Marmara Res Ctr, Mat Inst, Gebze, Turkey", 
      "name": "Yilmaz, Ozgur"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey", 
      "name": "Bozkir, Asuman"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) range, which is one of the most recognized factors that governs the self-assembly of amphiphilic copolymers, for the first time. The findings indicate that PEtOx-b-PLA copolymers, containing PEtOx fractions of varied lengths, self-assemble to form polymersomes in the range of 98.35 to 119.50 nm. The encapsulation potential of PEtOx-b-PLA polymersomes was demonstrated by loading of docetaxel (hydrophobic) with 17.90% encapsulation efficiency and by loading of pDNA (hydrophilic) with 65.03% encapsulation efficiency. In addition, size distribution profiles showed that polymersomes are colloidally stable for 24 h at 37 degrees C and for 3 months at +4 degrees C. The cell viability results showed that PEtOx-b-PLA copolymer and polymersomes are not cytotoxic to HUVEC, HEK293 and hMSC cell lines.", 
  "headline": "Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation", 
  "identifier": 90691, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation", 
  "url": "https://aperta.ulakbim.gov.tr/record/90691"
}