1 Ocak 2019 Dergi makalesi Açık Erişim

Oz, Umut Can; Kucukturkmen, Berrin; Ozkose, Umut Ugur; Gulyuz, Sevgi; Bolat, Zeynep Busra; Telci, Dilek; Sahin, Fikrettin; Yilmaz, Ozgur; Bozkir, Asuman

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    "creators": [
      {
        "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey", 
        "name": "Oz, Umut Can"
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      {
        "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey", 
        "name": "Kucukturkmen, Berrin"
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      {
        "name": "Ozkose, Umut Ugur"
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      {
        "name": "Gulyuz, Sevgi"
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      {
        "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey", 
        "name": "Bolat, Zeynep Busra"
      }, 
      {
        "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey", 
        "name": "Telci, Dilek"
      }, 
      {
        "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey", 
        "name": "Sahin, Fikrettin"
      }, 
      {
        "affiliation": "TUBITAK, Marmara Res Ctr, Mat Inst, Gebze, Turkey", 
        "name": "Yilmaz, Ozgur"
      }, 
      {
        "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey", 
        "name": "Bozkir, Asuman"
      }
    ], 
    "description": "Polymersomes are vesicular constructs formed by the self-assembly of polymer amphiphiles. Here we report the fabrication of PEtOx-b-PLA polymersomes at physiological pH/salt concentration and the determination of a f(PEtOx) range, which is one of the most recognized factors that governs the self-assembly of amphiphilic copolymers, for the first time. The findings indicate that PEtOx-b-PLA copolymers, containing PEtOx fractions of varied lengths, self-assemble to form polymersomes in the range of 98.35 to 119.50 nm. The encapsulation potential of PEtOx-b-PLA polymersomes was demonstrated by loading of docetaxel (hydrophobic) with 17.90% encapsulation efficiency and by loading of pDNA (hydrophilic) with 65.03% encapsulation efficiency. In addition, size distribution profiles showed that polymersomes are colloidally stable for 24 h at 37 degrees C and for 3 months at +4 degrees C. The cell viability results showed that PEtOx-b-PLA copolymer and polymersomes are not cytotoxic to HUVEC, HEK293 and hMSC cell lines.", 
    "doi": "10.1002/cnma.201800606", 
    "has_grant": false, 
    "journal": {
      "issue": "6", 
      "pages": "766-775", 
      "title": "CHEMNANOMAT", 
      "volume": "5"
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    "license": {
      "id": "cc-by"
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    "publication_date": "2019-01-01", 
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      "title": "Dergi makalesi", 
      "type": "publication"
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    "title": "Design of Colloidally Stable and Non-Toxic Petox-Based Polymersomes for Cargo Molecule Encapsulation"
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