1 Ocak 2018 Dergi makalesi Açık Erişim

Akkoc, Tunc; Genc, Deniz; Zibandeh, Noushin; Akkoc, Tolga

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    "creators": [
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        "affiliation": "Marmara Univ, Div Pediat Allergy & Immunol, Fac Med, Istanbul, Turkey", 
        "name": "Akkoc, Tunc"
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      {
        "affiliation": "Marmara Univ, Div Pediat Allergy & Immunol, Fac Med, Istanbul, Turkey", 
        "name": "Genc, Deniz"
      }, 
      {
        "affiliation": "Marmara Univ, Div Pediat Allergy & Immunol, Fac Med, Istanbul, Turkey", 
        "name": "Zibandeh, Noushin"
      }, 
      {
        "affiliation": "Sci & Technol Res Council Turkey, Marmara Res Ctr, Kocaeli, Turkey", 
        "name": "Akkoc, Tolga"
      }
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    "description": "Allergen-specific immunotherapy to induce T regulatory cells in the periphery has been used to treat allergic diseases. Mycobacteria can be used as an adjuvant for inducing T regulatory cells. However, it is unclear whether intranasal immunotherapy in combination with Mycobacteria adjuvant induces regulatory T cell differentiation and attenuates allergic responses in vivo. To investigate the role of intranasal ovalbumin (OVA) treatment alone and in combination with Mycobacteria vaccae, proportions of FoxP3(+) regulatory T cells and anti-inflammatory responses were evaluated in a murine model of asthma that was established in three groups of bicistronic Foxp3(EGFP) reporter BALB/c mice. Before establishment of the asthma model, two groups of mice received intranasal OVA immunotherapy and one also received simultaneous s.c. M. vaccae. Expression of CD4(+)CD25(+)Foxp3(+EGFP+) T cells in the lung and spleen was analyzed by flow cytometry and the cytokine profiles of allergen-stimulated lung and spleen lymphocytes assessed. The intranasal OVA immunotherapy group showed greater expression of CD4(+)CD25(+)Foxp3(+EGFP+) T cells in the spleen whereas in the group that also received M. vaccae such greater expression was demonstrated in the lung. Additionally, the proportion of IL-10 and IFN--secreting splenocytes was greater in the intranasal OVA+M. vaccae group. CD25 neutralization decreased CD4(+)Foxp3(+) cells more than other groups. In parallel with this finding, production of IL-10 and IFN- was down-regulated. Mucosal administration of OVA antigen results in a greater proportion of CD4(+)Foxp3(+) T cells in the spleen. IL-10 and IFN- induced by intranasal OVA immunotherapy and M. vaccae administration is down-regulated after CD25 neutralization.", 
    "doi": "10.1111/1348-0421.12634", 
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    "journal": {
      "issue": "8", 
      "pages": "531-540", 
      "title": "MICROBIOLOGY AND IMMUNOLOGY", 
      "volume": "62"
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      "id": "cc-by"
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    "publication_date": "2018-01-01", 
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    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
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    "title": "Intranasal ovalbumin immunotherapy with mycobacterial adjuvant promotes regulatory T cell accumulation in lung tissues"
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