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Bagdas, Deniz; Targowska-Duda, Katarzyna M.; Lopez, Jhon J.; Perez, Edwin G.; Arias, Hugo R.; Damaj, M. Imad
<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> <dc:creator>Bagdas, Deniz</dc:creator> <dc:creator>Targowska-Duda, Katarzyna M.</dc:creator> <dc:creator>Lopez, Jhon J.</dc:creator> <dc:creator>Perez, Edwin G.</dc:creator> <dc:creator>Arias, Hugo R.</dc:creator> <dc:creator>Damaj, M. Imad</dc:creator> <dc:date>2015-01-01</dc:date> <dc:description>BACKGROUND: Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. In this regard, selective 7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative 7-selective type II PAM, attenuates experimental inflammatory and neuropathic pains in mice.</dc:description> <dc:identifier>https://aperta.ulakbim.gov.trrecord/78255</dc:identifier> <dc:identifier>oai:zenodo.org:78255</dc:identifier> <dc:rights>info:eu-repo/semantics/openAccess</dc:rights> <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights> <dc:source>ANESTHESIA AND ANALGESIA 121(5) 1369-1377</dc:source> <dc:title>The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptors in Mice</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> <dc:type>publication-article</dc:type> </oai_dc:dc>
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