1 Ocak 2015 Dergi makalesi Açık Erişim

Bagdas, Deniz; Targowska-Duda, Katarzyna M.; Lopez, Jhon J.; Perez, Edwin G.; Arias, Hugo R.; Damaj, M. Imad

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        "name": "Bagdas, Deniz"
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        "affiliation": "Med Univ Lublin, Dept Biopharm, Lab Med Chem & Neuroengn, Lublin, Poland", 
        "name": "Targowska-Duda, Katarzyna M."
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      {
        "name": "Lopez, Jhon J."
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      {
        "affiliation": "Pontificia Univ Catolica Chile, Fac Chem, Dept Organ Chem, Santiago, Chile", 
        "name": "Perez, Edwin G."
      }, 
      {
        "affiliation": "Calif Northstate Univ, Coll Med, Dept Med Educ, Elk Grove, CA USA", 
        "name": "Arias, Hugo R."
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      {
        "affiliation": "Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA", 
        "name": "Damaj, M. Imad"
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    "description": "BACKGROUND: Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. In this regard, selective 7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative 7-selective type II PAM, attenuates experimental inflammatory and neuropathic pains in mice.", 
    "doi": "10.1213/ANE.0000000000000902", 
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    "journal": {
      "issue": "5", 
      "pages": "1369-1377", 
      "title": "ANESTHESIA AND ANALGESIA", 
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    "title": "The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptors in Mice"
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