1 Ocak 2015 Dergi makalesi Açık Erişim

Bagdas, Deniz; Targowska-Duda, Katarzyna M.; Lopez, Jhon J.; Perez, Edwin G.; Arias, Hugo R.; Damaj, M. Imad

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  "@context": "https://schema.org/", 
  "@id": 78255, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Bagdas, Deniz"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Med Univ Lublin, Dept Biopharm, Lab Med Chem & Neuroengn, Lublin, Poland", 
      "name": "Targowska-Duda, Katarzyna M."
    }, 
    {
      "@type": "Person", 
      "name": "Lopez, Jhon J."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Pontificia Univ Catolica Chile, Fac Chem, Dept Organ Chem, Santiago, Chile", 
      "name": "Perez, Edwin G."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Calif Northstate Univ, Coll Med, Dept Med Educ, Elk Grove, CA USA", 
      "name": "Arias, Hugo R."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA", 
      "name": "Damaj, M. Imad"
    }
  ], 
  "datePublished": "2015-01-01", 
  "description": "BACKGROUND: Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. In this regard, selective 7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative 7-selective type II PAM, attenuates experimental inflammatory and neuropathic pains in mice.", 
  "headline": "The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptors in Mice", 
  "identifier": 78255, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptors in Mice", 
  "url": "https://aperta.ulakbim.gov.tr/record/78255"
}