1 Ocak 2015 Dergi makalesi Açık Erişim

Bagdas, Deniz; Targowska-Duda, Katarzyna M.; Lopez, Jhon J.; Perez, Edwin G.; Arias, Hugo R.; Damaj, M. Imad

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/78255</identifier>
  <creators>
    <creator>
      <creatorName>Bagdas, Deniz</creatorName>
      <givenName>Deniz</givenName>
      <familyName>Bagdas</familyName>
    </creator>
    <creator>
      <creatorName>Targowska-Duda, Katarzyna M.</creatorName>
      <givenName>Katarzyna M.</givenName>
      <familyName>Targowska-Duda</familyName>
      <affiliation>Med Univ Lublin, Dept Biopharm, Lab Med Chem &amp; Neuroengn, Lublin, Poland</affiliation>
    </creator>
    <creator>
      <creatorName>Lopez, Jhon J.</creatorName>
      <givenName>Jhon J.</givenName>
      <familyName>Lopez</familyName>
    </creator>
    <creator>
      <creatorName>Perez, Edwin G.</creatorName>
      <givenName>Edwin G.</givenName>
      <familyName>Perez</familyName>
      <affiliation>Pontificia Univ Catolica Chile, Fac Chem, Dept Organ Chem, Santiago, Chile</affiliation>
    </creator>
    <creator>
      <creatorName>Arias, Hugo R.</creatorName>
      <givenName>Hugo R.</givenName>
      <familyName>Arias</familyName>
      <affiliation>Calif Northstate Univ, Coll Med, Dept Med Educ, Elk Grove, CA USA</affiliation>
    </creator>
    <creator>
      <creatorName>Damaj, M. Imad</creatorName>
      <givenName>M. Imad</givenName>
      <familyName>Damaj</familyName>
      <affiliation>Virginia Commonwealth Univ, Dept Pharmacol &amp; Toxicol, Richmond, VA 23298 USA</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Antinociceptive And Antiinflammatory Properties Of 3-Furan-2-Yl-N-P-Tolyl-Acrylamide, A Positive Allosteric Modulator Of Alpha 7 Nicotinic Acetylcholine Receptors In Mice</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/78255</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1213/ANE.0000000000000902</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">BACKGROUND: Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. In this regard, selective 7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative 7-selective type II PAM, attenuates experimental inflammatory and neuropathic pains in mice.</description>
  </descriptions>
</resource>