1 Ocak 2015 Dergi makalesi Açık Erişim

Yuce-Artun, Nazan; Ozel Kizil, Erguvan Tugba; Baskak, Bora; Ozguven, Halise Devrimci; Duydu, Yalcin; Suzen, Halit Sinan

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  <dc:creator>Yuce-Artun, Nazan</dc:creator>
  <dc:creator>Ozel Kizil, Erguvan Tugba</dc:creator>
  <dc:creator>Baskak, Bora</dc:creator>
  <dc:creator>Ozguven, Halise Devrimci</dc:creator>
  <dc:creator>Duydu, Yalcin</dc:creator>
  <dc:creator>Suzen, Halit Sinan</dc:creator>
  <dc:date>2015-01-01</dc:date>
  <dc:description>A fast, simple and sensitive high-pressure liquid chromatography (HPLC) method with UV detection was developed for frequently prescribed antidepressant, sertraline (SERT) and its main metabolite N-desmethylsertraline (DSERT), in human plasma. SERT and DSERT were extracted by an optimized solid phase chromatographic (SPE) method using C-18 cartridges and Clomipramine was used as external standard (ES). The analytes were separated on C18, 4.6 mm x 150 mm, 5 pm column at 50 degrees C with a mobile phase of 45% acetonitrile + 55% NaH2PO4 at a flow rate of 0.4 mL/min. Detector responses monitored at 4 different wave-lengths; 200-205-210-215 nm. The method proved to be rapid and effective for the plasma sample analyses of therapeutic drug monitoring for sertraline treated patients.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/77675</dc:identifier>
  <dc:identifier>oai:zenodo.org:77675</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>REVUE ROUMAINE DE CHIMIE 60(5-6) 543-548</dc:source>
  <dc:title>DETERMINATION OF SERTRALINE AND ITS METABOLITE BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY IN PLASMA</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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