1 Ocak 2015 Dergi makalesi Açık Erişim

Yuce-Artun, Nazan; Ozel Kizil, Erguvan Tugba; Baskak, Bora; Ozguven, Halise Devrimci; Duydu, Yalcin; Suzen, Halit Sinan

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{
  "@context": "https://schema.org/", 
  "@id": 77675, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Inst Biotechnol, TR-06100 Ankara, Turkey", 
      "name": "Yuce-Artun, Nazan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Sch Med, Dept Psychiat, TR-06100 Ankara, Turkey", 
      "name": "Ozel Kizil, Erguvan Tugba"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Sch Med, Dept Psychiat, TR-06100 Ankara, Turkey", 
      "name": "Baskak, Bora"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Sch Med, Dept Psychiat, TR-06100 Ankara, Turkey", 
      "name": "Ozguven, Halise Devrimci"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Pharm, Dept Toxicol, TR-06100 Ankara, Turkey", 
      "name": "Duydu, Yalcin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Pharm, Dept Toxicol, TR-06100 Ankara, Turkey", 
      "name": "Suzen, Halit Sinan"
    }
  ], 
  "datePublished": "2015-01-01", 
  "description": "A fast, simple and sensitive high-pressure liquid chromatography (HPLC) method with UV detection was developed for frequently prescribed antidepressant, sertraline (SERT) and its main metabolite N-desmethylsertraline (DSERT), in human plasma. SERT and DSERT were extracted by an optimized solid phase chromatographic (SPE) method using C-18 cartridges and Clomipramine was used as external standard (ES). The analytes were separated on C18, 4.6 mm x 150 mm, 5 pm column at 50 degrees C with a mobile phase of 45% acetonitrile + 55% NaH2PO4 at a flow rate of 0.4 mL/min. Detector responses monitored at 4 different wave-lengths; 200-205-210-215 nm. The method proved to be rapid and effective for the plasma sample analyses of therapeutic drug monitoring for sertraline treated patients.", 
  "headline": "DETERMINATION OF SERTRALINE AND ITS METABOLITE BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY IN PLASMA", 
  "identifier": 77675, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "DETERMINATION OF SERTRALINE AND ITS METABOLITE BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY IN PLASMA", 
  "url": "https://aperta.ulakbim.gov.tr/record/77675"
}