1 Ocak 2015 Dergi makalesi Açık Erişim

Yuce-Artun, Nazan; Ozel Kizil, Erguvan Tugba; Baskak, Bora; Ozguven, Halise Devrimci; Duydu, Yalcin; Suzen, Halit Sinan

Citation Style Language JSON

{
  "URL": "https://aperta.ulakbim.gov.tr/record/77675", 
  "abstract": "A fast, simple and sensitive high-pressure liquid chromatography (HPLC) method with UV detection was developed for frequently prescribed antidepressant, sertraline (SERT) and its main metabolite N-desmethylsertraline (DSERT), in human plasma. SERT and DSERT were extracted by an optimized solid phase chromatographic (SPE) method using C-18 cartridges and Clomipramine was used as external standard (ES). The analytes were separated on C18, 4.6 mm x 150 mm, 5 pm column at 50 degrees C with a mobile phase of 45% acetonitrile + 55% NaH2PO4 at a flow rate of 0.4 mL/min. Detector responses monitored at 4 different wave-lengths; 200-205-210-215 nm. The method proved to be rapid and effective for the plasma sample analyses of therapeutic drug monitoring for sertraline treated patients.", 
  "author": [
    {
      "family": "Yuce-Artun", 
      "given": " Nazan"
    }, 
    {
      "family": "Ozel Kizil", 
      "given": " Erguvan Tugba"
    }, 
    {
      "family": "Baskak", 
      "given": " Bora"
    }, 
    {
      "family": "Ozguven", 
      "given": " Halise Devrimci"
    }, 
    {
      "family": "Duydu", 
      "given": " Yalcin"
    }, 
    {
      "family": "Suzen", 
      "given": " Halit Sinan"
    }
  ], 
  "container_title": "REVUE ROUMAINE DE CHIMIE", 
  "id": "77675", 
  "issue": "5-6", 
  "issued": {
    "date-parts": [
      [
        2015, 
        1, 
        1
      ]
    ]
  }, 
  "page": "543-548", 
  "title": "DETERMINATION OF SERTRALINE AND ITS METABOLITE BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY IN PLASMA", 
  "type": "article-journal", 
  "volume": "60"
}