1 Ocak 2015 Dergi makalesi Açık Erişim

Yuce-Artun, Nazan; Ozel Kizil, Erguvan Tugba; Baskak, Bora; Ozguven, Halise Devrimci; Duydu, Yalcin; Suzen, Halit Sinan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/77675</identifier>
  <creators>
    <creator>
      <creatorName>Yuce-Artun, Nazan</creatorName>
      <givenName>Nazan</givenName>
      <familyName>Yuce-Artun</familyName>
      <affiliation>Ankara Univ, Inst Biotechnol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozel Kizil, Erguvan Tugba</creatorName>
      <givenName>Erguvan Tugba</givenName>
      <familyName>Ozel Kizil</familyName>
      <affiliation>Ankara Univ, Sch Med, Dept Psychiat, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Baskak, Bora</creatorName>
      <givenName>Bora</givenName>
      <familyName>Baskak</familyName>
      <affiliation>Ankara Univ, Sch Med, Dept Psychiat, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozguven, Halise Devrimci</creatorName>
      <givenName>Halise Devrimci</givenName>
      <familyName>Ozguven</familyName>
      <affiliation>Ankara Univ, Sch Med, Dept Psychiat, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Duydu, Yalcin</creatorName>
      <givenName>Yalcin</givenName>
      <familyName>Duydu</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Toxicol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Suzen, Halit Sinan</creatorName>
      <givenName>Halit Sinan</givenName>
      <familyName>Suzen</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Toxicol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Determination Of Sertraline And Its Metabolite By High-Pressure Liquid Chromatography In Plasma</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/77675</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.81043/aperta.77674</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.81043/aperta.77675</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">A fast, simple and sensitive high-pressure liquid chromatography (HPLC) method with UV detection was developed for frequently prescribed antidepressant, sertraline (SERT) and its main metabolite N-desmethylsertraline (DSERT), in human plasma. SERT and DSERT were extracted by an optimized solid phase chromatographic (SPE) method using C-18 cartridges and Clomipramine was used as external standard (ES). The analytes were separated on C18, 4.6 mm x 150 mm, 5 pm column at 50 degrees C with a mobile phase of 45% acetonitrile + 55% NaH2PO4 at a flow rate of 0.4 mL/min. Detector responses monitored at 4 different wave-lengths; 200-205-210-215 nm. The method proved to be rapid and effective for the plasma sample analyses of therapeutic drug monitoring for sertraline treated patients.</description>
  </descriptions>
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