1 Ocak 2019 Dergi makalesi Açık Erişim

Koprulu, Tugba Kul; Okten, Salih; Tekin, Saban; Cakmak, Osman

Dublin Core

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  <dc:creator>Koprulu, Tugba Kul</dc:creator>
  <dc:creator>Okten, Salih</dc:creator>
  <dc:creator>Tekin, Saban</dc:creator>
  <dc:creator>Cakmak, Osman</dc:creator>
  <dc:date>2019-01-01</dc:date>
  <dc:description>Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/74993</dc:identifier>
  <dc:identifier>oai:zenodo.org:74993</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 33(3)</dc:source>
  <dc:title>Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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