1 Ocak 2019 Dergi makalesi Açık Erişim

Koprulu, Tugba Kul; Okten, Salih; Tekin, Saban; Cakmak, Osman

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/74993</identifier>
  <creators>
    <creator>
      <creatorName>Koprulu, Tugba Kul</creatorName>
      <givenName>Tugba Kul</givenName>
      <familyName>Koprulu</familyName>
      <affiliation>Gaziosmanpasa Univ, Sci &amp; Technol Res &amp; Applicat Ctr, Div Mol Biol, TR-60200 Tokat, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Okten, Salih</creatorName>
      <givenName>Salih</givenName>
      <familyName>Okten</familyName>
      <affiliation>Kirikkale Univ, Dept Maths &amp; Sci Educ, Fac Educ, TR-71450 Yahsihan, Kirikkale, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekin, Saban</creatorName>
      <givenName>Saban</givenName>
      <familyName>Tekin</familyName>
      <affiliation>Univ Hlth Sci, Dept Basic Med Sci, Fac Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cakmak, Osman</creatorName>
      <givenName>Osman</givenName>
      <familyName>Cakmak</familyName>
      <affiliation>Yildiz Tech Univ, Fac Art &amp; Sci, Dept Chem, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Biological Evaluation Of Some Quinoline Derivatives With Different Functional Groups As Anticancer Agents</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/74993</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/jbt.22260</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.</description>
  </descriptions>
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