1 Ocak 2019 Dergi makalesi Açık Erişim

Koprulu, Tugba Kul; Okten, Salih; Tekin, Saban; Cakmak, Osman

Citation Style Language JSON

{
  "DOI": "10.1002/jbt.22260", 
  "abstract": "Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.", 
  "author": [
    {
      "family": "Koprulu", 
      "given": " Tugba Kul"
    }, 
    {
      "family": "Okten", 
      "given": " Salih"
    }, 
    {
      "family": "Tekin", 
      "given": " Saban"
    }, 
    {
      "family": "Cakmak", 
      "given": " Osman"
    }
  ], 
  "container_title": "JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY", 
  "id": "74993", 
  "issue": "3", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents", 
  "type": "article-journal", 
  "volume": "33"
}