1 Ocak 2019 Dergi makalesi Açık Erişim

Koprulu, Tugba Kul; Okten, Salih; Tekin, Saban; Cakmak, Osman

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  "@context": "https://schema.org/", 
  "@id": 74993, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Gaziosmanpasa Univ, Sci & Technol Res & Applicat Ctr, Div Mol Biol, TR-60200 Tokat, Turkey", 
      "name": "Koprulu, Tugba Kul"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Kirikkale Univ, Dept Maths & Sci Educ, Fac Educ, TR-71450 Yahsihan, Kirikkale, Turkey", 
      "name": "Okten, Salih"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Hlth Sci, Dept Basic Med Sci, Fac Med, Istanbul, Turkey", 
      "name": "Tekin, Saban"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yildiz Tech Univ, Fac Art & Sci, Dept Chem, Istanbul, Turkey", 
      "name": "Cakmak, Osman"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.", 
  "headline": "Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents", 
  "identifier": 74993, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents", 
  "url": "https://aperta.ulakbim.gov.tr/record/74993"
}