1 Ocak 2019 Dergi makalesi Açık Erişim

Koprulu, Tugba Kul; Okten, Salih; Tekin, Saban; Cakmak, Osman

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        "affiliation": "Gaziosmanpasa Univ, Sci & Technol Res & Applicat Ctr, Div Mol Biol, TR-60200 Tokat, Turkey", 
        "name": "Koprulu, Tugba Kul"
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      {
        "affiliation": "Kirikkale Univ, Dept Maths & Sci Educ, Fac Educ, TR-71450 Yahsihan, Kirikkale, Turkey", 
        "name": "Okten, Salih"
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      {
        "affiliation": "Univ Hlth Sci, Dept Basic Med Sci, Fac Med, Istanbul, Turkey", 
        "name": "Tekin, Saban"
      }, 
      {
        "affiliation": "Yildiz Tech Univ, Fac Art & Sci, Dept Chem, Istanbul, Turkey", 
        "name": "Cakmak, Osman"
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    "description": "Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.", 
    "doi": "10.1002/jbt.22260", 
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    "journal": {
      "issue": "3", 
      "title": "JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY", 
      "volume": "33"
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    "title": "Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents"
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