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Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors

Kilic, Burcu; Erdogan, Merve; Gulcan, Hayrettin O.; Aksakarl, Fatma; Oruklu, Nihan; Bagriacik, Emin U.; Dogruer, Deniz S.


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  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey", 
      "name": "Kilic, Burcu"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey", 
      "name": "Erdogan, Merve"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Eastern Mediterranean Univ, Fac Pharm, Dept Pharmaceut Chem, Gazimagosa, North Cyprus, Turkey", 
      "name": "Gulcan, Hayrettin O."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Chem, Ankara, Turkey", 
      "name": "Aksakarl, Fatma"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Fac Med, Dept Immunol, Ankara, Turkey", 
      "name": "Oruklu, Nihan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Fac Med, Dept Immunol, Ankara, Turkey", 
      "name": "Bagriacik, Emin U."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey", 
      "name": "Dogruer, Deniz S."
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.", 
  "headline": "Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors", 
  "identifier": 72229, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors", 
  "url": "https://aperta.ulakbim.gov.tr/record/72229"
}
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