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Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors

Kilic, Burcu; Erdogan, Merve; Gulcan, Hayrettin O.; Aksakarl, Fatma; Oruklu, Nihan; Bagriacik, Emin U.; Dogruer, Deniz S.


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    <creator>
      <creatorName>Kilic, Burcu</creatorName>
      <givenName>Burcu</givenName>
      <familyName>Kilic</familyName>
      <affiliation>Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey</affiliation>
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    <creator>
      <creatorName>Erdogan, Merve</creatorName>
      <givenName>Merve</givenName>
      <familyName>Erdogan</familyName>
      <affiliation>Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey</affiliation>
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    <creator>
      <creatorName>Gulcan, Hayrettin O.</creatorName>
      <givenName>Hayrettin O.</givenName>
      <familyName>Gulcan</familyName>
      <affiliation>Eastern Mediterranean Univ, Fac Pharm, Dept Pharmaceut Chem, Gazimagosa, North Cyprus, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aksakarl, Fatma</creatorName>
      <givenName>Fatma</givenName>
      <familyName>Aksakarl</familyName>
      <affiliation>Hacettepe Univ, Dept Chem, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oruklu, Nihan</creatorName>
      <givenName>Nihan</givenName>
      <familyName>Oruklu</familyName>
      <affiliation>Gazi Univ, Fac Med, Dept Immunol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bagriacik, Emin U.</creatorName>
      <givenName>Emin U.</givenName>
      <familyName>Bagriacik</familyName>
      <affiliation>Gazi Univ, Fac Med, Dept Immunol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dogruer, Deniz S.</creatorName>
      <givenName>Deniz S.</givenName>
      <familyName>Dogruer</familyName>
      <affiliation>Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey</affiliation>
    </creator>
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  <titles>
    <title>Design, Synthesis And Investigation Of New Diphenyl Substituted Pyridazinone Derivatives As Both Cholinesterase And A Beta-Aggregation Inhibitors</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
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    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.2174/1573406414666180524073241</relatedIdentifier>
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  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.</description>
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