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Atolani, O.; Areh, E. T.; Oguntoye, O. S.; Zubair, M. F.; Fabiyi, O. A.; Oyegoke, R. A.; Tarigha, D. E.; Adamu, N.; Adeyemi, O. S.; Kambizi, L.; Olatunji, G. A.
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Chemical composition, antioxidant, anti-lipooxygenase, antimicrobial, anti-parasite and cytotoxic activities of Polyalthia longifolia seed oil</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">MEDICINAL CHEMISTRY RESEARCH</subfield> <subfield code="v">28</subfield> <subfield code="n">4</subfield> <subfield code="c">515-527</subfield> </datafield> <controlfield tag="001">67385</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">This work investigates the chemical compositions of Polyalthia longifolia Thw. seed oil with the associated antioxidant, anti-inflammatory, anti-parasite and cytotoxicity potentials. The oil of P. longifolia seed obtained by soxhlet extraction was trans-esterified and the fatty acid profile characterized using gas chromatography mass spectrometry (GC-MS). The antioxidant activity was evaluated using DPPH and ABTS assays. The anti-bacterial and anti-fungi properties of the oil were determine on clinical isolates of the organisms using agar diffusion method. The anti-inflammatory activities, cytotoxicity and anti-parasite potential were evaluated using lipooxygenase, mammalian cell and Toxoplasma gondii assays respectively. P. longifolia seed was observed to contain oleic (30.31%), linoleic acid (19.27%) and palmitic acid (15.11%) as the major fatty acids with low proportion of tricosylic acid (6.10) and stearic acid (5.56%). The oil had significant anti-lipooxygenase activity (IC50=0.70 +/- 0.02 mu g/mL) comparable to indomethacin (IC50=0.53 +/- 0.07 mu g/mL). The DPPH (IC50=55.91 +/- 31.18 mu g/mL) and ABTS (IC50=16.89 +/- 15.50 mu g/mL) antioxidant activity of the oil was lower to the ascorbic acid (IC50=0.34 +/- 0.04 and 0.54 +/- 0.04 mu g/mL). The oil also showed activities against all the tested bacteria and fungi. The highest inhibition was recorded against S. aureus (17 +/- 1mm) at concentration 200mg/mL. Further, the oils showed strong potential to restrict growth of Toxoplasma gondii in vitro, but the parasite growth inhibition was mildly abated in the presence of -tocopherol. The seed oil of the underutilized P. longifolia possesses essential fatty acids which could be responsible for the numerous biological potentials which include anti-lipooxygenase, antioxidant, anti-inflammatory, anti-parasite, anti-microbial and cytotoxic activities. The incorporation of the natural oil into pharmaceuticals or cosmetics may enhance antioxidant, anti-inflammatory, antimicrobial and cytotoxicity potential of such products.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria</subfield> <subfield code="a">Areh, E. T.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria</subfield> <subfield code="a">Oguntoye, O. S.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Ilorin, Dept Ind Chem, PMB 1515, Ilorin, Nigeria</subfield> <subfield code="a">Zubair, M. F.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Ilorin, Dept Crop Protect, PMB 1515, Ilorin, Nigeria</subfield> <subfield code="a">Fabiyi, O. A.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Ilorin, Dept Biochem, PMB 1515, Ilorin, Nigeria</subfield> <subfield code="a">Oyegoke, R. A.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria</subfield> <subfield code="a">Tarigha, D. E.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Ilorin, Dept Ind Chem, PMB 1515, Ilorin, Nigeria</subfield> <subfield code="a">Adamu, N.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Landmark Univ, Dept Biochem, Med Biochem & Toxicol Lab, Omu Aran 251101, Kwara State, Nigeria</subfield> <subfield code="a">Adeyemi, O. S.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Cape Peninsula Univ Technol, Dept Hort, Cape Town, South Africa</subfield> <subfield code="a">Kambizi, L.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Olatunji, G. A.</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria</subfield> <subfield code="a">Atolani, O.</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2019-01-01</subfield> </datafield> <controlfield tag="005">20210316023418.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:67385</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:bd75486230fa51d276f6cb00dff307a2</subfield> <subfield code="s">335</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/67385/files/bib-608f0497-7910-4634-98af-e4fa96b4ee4b.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1007/s00044-019-02301-z</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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