1 Ocak 2019 Dergi makalesi Açık Erişim

Atolani, O.; Areh, E. T.; Oguntoye, O. S.; Zubair, M. F.; Fabiyi, O. A.; Oyegoke, R. A.; Tarigha, D. E.; Adamu, N.; Adeyemi, O. S.; Kambizi, L.; Olatunji, G. A.

Dublin Core

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  <dc:creator>Atolani, O.</dc:creator>
  <dc:creator>Areh, E. T.</dc:creator>
  <dc:creator>Oguntoye, O. S.</dc:creator>
  <dc:creator>Zubair, M. F.</dc:creator>
  <dc:creator>Fabiyi, O. A.</dc:creator>
  <dc:creator>Oyegoke, R. A.</dc:creator>
  <dc:creator>Tarigha, D. E.</dc:creator>
  <dc:creator>Adamu, N.</dc:creator>
  <dc:creator>Adeyemi, O. S.</dc:creator>
  <dc:creator>Kambizi, L.</dc:creator>
  <dc:creator>Olatunji, G. A.</dc:creator>
  <dc:date>2019-01-01</dc:date>
  <dc:description>This work investigates the chemical compositions of Polyalthia longifolia Thw. seed oil with the associated antioxidant, anti-inflammatory, anti-parasite and cytotoxicity potentials. The oil of P. longifolia seed obtained by soxhlet extraction was trans-esterified and the fatty acid profile characterized using gas chromatography mass spectrometry (GC-MS). The antioxidant activity was evaluated using DPPH and ABTS assays. The anti-bacterial and anti-fungi properties of the oil were determine on clinical isolates of the organisms using agar diffusion method. The anti-inflammatory activities, cytotoxicity and anti-parasite potential were evaluated using lipooxygenase, mammalian cell and Toxoplasma gondii assays respectively. P. longifolia seed was observed to contain oleic (30.31%), linoleic acid (19.27%) and palmitic acid (15.11%) as the major fatty acids with low proportion of tricosylic acid (6.10) and stearic acid (5.56%). The oil had significant anti-lipooxygenase activity (IC50=0.70 +/- 0.02 mu g/mL) comparable to indomethacin (IC50=0.53 +/- 0.07 mu g/mL). The DPPH (IC50=55.91 +/- 31.18 mu g/mL) and ABTS (IC50=16.89 +/- 15.50 mu g/mL) antioxidant activity of the oil was lower to the ascorbic acid (IC50=0.34 +/- 0.04 and 0.54 +/- 0.04 mu g/mL). The oil also showed activities against all the tested bacteria and fungi. The highest inhibition was recorded against S. aureus (17 +/- 1mm) at concentration 200mg/mL. Further, the oils showed strong potential to restrict growth of Toxoplasma gondii in vitro, but the parasite growth inhibition was mildly abated in the presence of -tocopherol. The seed oil of the underutilized P. longifolia possesses essential fatty acids which could be responsible for the numerous biological potentials which include anti-lipooxygenase, antioxidant, anti-inflammatory, anti-parasite, anti-microbial and cytotoxic activities. The incorporation of the natural oil into pharmaceuticals or cosmetics may enhance antioxidant, anti-inflammatory, antimicrobial and cytotoxicity potential of such products.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/67385</dc:identifier>
  <dc:identifier>oai:zenodo.org:67385</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>MEDICINAL CHEMISTRY RESEARCH 28(4) 515-527</dc:source>
  <dc:title>Chemical composition, antioxidant, anti-lipooxygenase, antimicrobial, anti-parasite and cytotoxic activities of Polyalthia longifolia seed oil</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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