1 Ocak 2019 Dergi makalesi Açık Erişim

Atolani, O.; Areh, E. T.; Oguntoye, O. S.; Zubair, M. F.; Fabiyi, O. A.; Oyegoke, R. A.; Tarigha, D. E.; Adamu, N.; Adeyemi, O. S.; Kambizi, L.; Olatunji, G. A.

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    "creators": [
      {
        "affiliation": "Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria", 
        "name": "Atolani, O."
      }, 
      {
        "affiliation": "Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria", 
        "name": "Areh, E. T."
      }, 
      {
        "affiliation": "Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria", 
        "name": "Oguntoye, O. S."
      }, 
      {
        "affiliation": "Univ Ilorin, Dept Ind Chem, PMB 1515, Ilorin, Nigeria", 
        "name": "Zubair, M. F."
      }, 
      {
        "affiliation": "Univ Ilorin, Dept Crop Protect, PMB 1515, Ilorin, Nigeria", 
        "name": "Fabiyi, O. A."
      }, 
      {
        "affiliation": "Univ Ilorin, Dept Biochem, PMB 1515, Ilorin, Nigeria", 
        "name": "Oyegoke, R. A."
      }, 
      {
        "affiliation": "Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria", 
        "name": "Tarigha, D. E."
      }, 
      {
        "affiliation": "Univ Ilorin, Dept Ind Chem, PMB 1515, Ilorin, Nigeria", 
        "name": "Adamu, N."
      }, 
      {
        "affiliation": "Landmark Univ, Dept Biochem, Med Biochem & Toxicol Lab, Omu Aran 251101, Kwara State, Nigeria", 
        "name": "Adeyemi, O. S."
      }, 
      {
        "affiliation": "Cape Peninsula Univ Technol, Dept Hort, Cape Town, South Africa", 
        "name": "Kambizi, L."
      }, 
      {
        "name": "Olatunji, G. A."
      }
    ], 
    "description": "This work investigates the chemical compositions of Polyalthia longifolia Thw. seed oil with the associated antioxidant, anti-inflammatory, anti-parasite and cytotoxicity potentials. The oil of P. longifolia seed obtained by soxhlet extraction was trans-esterified and the fatty acid profile characterized using gas chromatography mass spectrometry (GC-MS). The antioxidant activity was evaluated using DPPH and ABTS assays. The anti-bacterial and anti-fungi properties of the oil were determine on clinical isolates of the organisms using agar diffusion method. The anti-inflammatory activities, cytotoxicity and anti-parasite potential were evaluated using lipooxygenase, mammalian cell and Toxoplasma gondii assays respectively. P. longifolia seed was observed to contain oleic (30.31%), linoleic acid (19.27%) and palmitic acid (15.11%) as the major fatty acids with low proportion of tricosylic acid (6.10) and stearic acid (5.56%). The oil had significant anti-lipooxygenase activity (IC50=0.70 +/- 0.02 mu g/mL) comparable to indomethacin (IC50=0.53 +/- 0.07 mu g/mL). The DPPH (IC50=55.91 +/- 31.18 mu g/mL) and ABTS (IC50=16.89 +/- 15.50 mu g/mL) antioxidant activity of the oil was lower to the ascorbic acid (IC50=0.34 +/- 0.04 and 0.54 +/- 0.04 mu g/mL). The oil also showed activities against all the tested bacteria and fungi. The highest inhibition was recorded against S. aureus (17 +/- 1mm) at concentration 200mg/mL. Further, the oils showed strong potential to restrict growth of Toxoplasma gondii in vitro, but the parasite growth inhibition was mildly abated in the presence of -tocopherol. The seed oil of the underutilized P. longifolia possesses essential fatty acids which could be responsible for the numerous biological potentials which include anti-lipooxygenase, antioxidant, anti-inflammatory, anti-parasite, anti-microbial and cytotoxic activities. The incorporation of the natural oil into pharmaceuticals or cosmetics may enhance antioxidant, anti-inflammatory, antimicrobial and cytotoxicity potential of such products.", 
    "doi": "10.1007/s00044-019-02301-z", 
    "has_grant": false, 
    "journal": {
      "issue": "4", 
      "pages": "515-527", 
      "title": "MEDICINAL CHEMISTRY RESEARCH", 
      "volume": "28"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2019-01-01", 
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    "resource_type": {
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      "title": "Dergi makalesi", 
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    "title": "Chemical composition, antioxidant, anti-lipooxygenase, antimicrobial, anti-parasite and cytotoxic activities of Polyalthia longifolia seed oil"
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