1 Ocak 2019 Dergi makalesi Açık Erişim

Atolani, O.; Areh, E. T.; Oguntoye, O. S.; Zubair, M. F.; Fabiyi, O. A.; Oyegoke, R. A.; Tarigha, D. E.; Adamu, N.; Adeyemi, O. S.; Kambizi, L.; Olatunji, G. A.

Citation Style Language JSON

{
  "DOI": "10.1007/s00044-019-02301-z", 
  "abstract": "This work investigates the chemical compositions of Polyalthia longifolia Thw. seed oil with the associated antioxidant, anti-inflammatory, anti-parasite and cytotoxicity potentials. The oil of P. longifolia seed obtained by soxhlet extraction was trans-esterified and the fatty acid profile characterized using gas chromatography mass spectrometry (GC-MS). The antioxidant activity was evaluated using DPPH and ABTS assays. The anti-bacterial and anti-fungi properties of the oil were determine on clinical isolates of the organisms using agar diffusion method. The anti-inflammatory activities, cytotoxicity and anti-parasite potential were evaluated using lipooxygenase, mammalian cell and Toxoplasma gondii assays respectively. P. longifolia seed was observed to contain oleic (30.31%), linoleic acid (19.27%) and palmitic acid (15.11%) as the major fatty acids with low proportion of tricosylic acid (6.10) and stearic acid (5.56%). The oil had significant anti-lipooxygenase activity (IC50=0.70 +/- 0.02 mu g/mL) comparable to indomethacin (IC50=0.53 +/- 0.07 mu g/mL). The DPPH (IC50=55.91 +/- 31.18 mu g/mL) and ABTS (IC50=16.89 +/- 15.50 mu g/mL) antioxidant activity of the oil was lower to the ascorbic acid (IC50=0.34 +/- 0.04 and 0.54 +/- 0.04 mu g/mL). The oil also showed activities against all the tested bacteria and fungi. The highest inhibition was recorded against S. aureus (17 +/- 1mm) at concentration 200mg/mL. Further, the oils showed strong potential to restrict growth of Toxoplasma gondii in vitro, but the parasite growth inhibition was mildly abated in the presence of -tocopherol. The seed oil of the underutilized P. longifolia possesses essential fatty acids which could be responsible for the numerous biological potentials which include anti-lipooxygenase, antioxidant, anti-inflammatory, anti-parasite, anti-microbial and cytotoxic activities. The incorporation of the natural oil into pharmaceuticals or cosmetics may enhance antioxidant, anti-inflammatory, antimicrobial and cytotoxicity potential of such products.", 
  "author": [
    {
      "family": "Atolani", 
      "given": " O."
    }, 
    {
      "family": "Areh", 
      "given": " E. T."
    }, 
    {
      "family": "Oguntoye", 
      "given": " O. S."
    }, 
    {
      "family": "Zubair", 
      "given": " M. F."
    }, 
    {
      "family": "Fabiyi", 
      "given": " O. A."
    }, 
    {
      "family": "Oyegoke", 
      "given": " R. A."
    }, 
    {
      "family": "Tarigha", 
      "given": " D. E."
    }, 
    {
      "family": "Adamu", 
      "given": " N."
    }, 
    {
      "family": "Adeyemi", 
      "given": " O. S."
    }, 
    {
      "family": "Kambizi", 
      "given": " L."
    }, 
    {
      "family": "Olatunji", 
      "given": " G. A."
    }
  ], 
  "container_title": "MEDICINAL CHEMISTRY RESEARCH", 
  "id": "67385", 
  "issue": "4", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "515-527", 
  "title": "Chemical composition, antioxidant, anti-lipooxygenase, antimicrobial, anti-parasite and cytotoxic activities of Polyalthia longifolia seed oil", 
  "type": "article-journal", 
  "volume": "28"
}