1 Ocak 2019 Dergi makalesi Açık Erişim

Atolani, O.; Areh, E. T.; Oguntoye, O. S.; Zubair, M. F.; Fabiyi, O. A.; Oyegoke, R. A.; Tarigha, D. E.; Adamu, N.; Adeyemi, O. S.; Kambizi, L.; Olatunji, G. A.

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/67385</identifier>
  <creators>
    <creator>
      <creatorName>Atolani, O.</creatorName>
      <givenName>O.</givenName>
      <familyName>Atolani</familyName>
      <affiliation>Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria</affiliation>
    </creator>
    <creator>
      <creatorName>Areh, E. T.</creatorName>
      <givenName>E. T.</givenName>
      <familyName>Areh</familyName>
      <affiliation>Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria</affiliation>
    </creator>
    <creator>
      <creatorName>Oguntoye, O. S.</creatorName>
      <givenName>O. S.</givenName>
      <familyName>Oguntoye</familyName>
      <affiliation>Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria</affiliation>
    </creator>
    <creator>
      <creatorName>Zubair, M. F.</creatorName>
      <givenName>M. F.</givenName>
      <familyName>Zubair</familyName>
      <affiliation>Univ Ilorin, Dept Ind Chem, PMB 1515, Ilorin, Nigeria</affiliation>
    </creator>
    <creator>
      <creatorName>Fabiyi, O. A.</creatorName>
      <givenName>O. A.</givenName>
      <familyName>Fabiyi</familyName>
      <affiliation>Univ Ilorin, Dept Crop Protect, PMB 1515, Ilorin, Nigeria</affiliation>
    </creator>
    <creator>
      <creatorName>Oyegoke, R. A.</creatorName>
      <givenName>R. A.</givenName>
      <familyName>Oyegoke</familyName>
      <affiliation>Univ Ilorin, Dept Biochem, PMB 1515, Ilorin, Nigeria</affiliation>
    </creator>
    <creator>
      <creatorName>Tarigha, D. E.</creatorName>
      <givenName>D. E.</givenName>
      <familyName>Tarigha</familyName>
      <affiliation>Univ Ilorin, Dept Chem, PMB 1515, Ilorin, Nigeria</affiliation>
    </creator>
    <creator>
      <creatorName>Adamu, N.</creatorName>
      <givenName>N.</givenName>
      <familyName>Adamu</familyName>
      <affiliation>Univ Ilorin, Dept Ind Chem, PMB 1515, Ilorin, Nigeria</affiliation>
    </creator>
    <creator>
      <creatorName>Adeyemi, O. S.</creatorName>
      <givenName>O. S.</givenName>
      <familyName>Adeyemi</familyName>
      <affiliation>Landmark Univ, Dept Biochem, Med Biochem &amp; Toxicol Lab, Omu Aran 251101, Kwara State, Nigeria</affiliation>
    </creator>
    <creator>
      <creatorName>Kambizi, L.</creatorName>
      <givenName>L.</givenName>
      <familyName>Kambizi</familyName>
      <affiliation>Cape Peninsula Univ Technol, Dept Hort, Cape Town, South Africa</affiliation>
    </creator>
    <creator>
      <creatorName>Olatunji, G. A.</creatorName>
      <givenName>G. A.</givenName>
      <familyName>Olatunji</familyName>
    </creator>
  </creators>
  <titles>
    <title>Chemical Composition, Antioxidant, Anti-Lipooxygenase, Antimicrobial, Anti-Parasite And Cytotoxic Activities Of Polyalthia Longifolia Seed Oil</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/67385</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s00044-019-02301-z</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">This work investigates the chemical compositions of Polyalthia longifolia Thw. seed oil with the associated antioxidant, anti-inflammatory, anti-parasite and cytotoxicity potentials. The oil of P. longifolia seed obtained by soxhlet extraction was trans-esterified and the fatty acid profile characterized using gas chromatography mass spectrometry (GC-MS). The antioxidant activity was evaluated using DPPH and ABTS assays. The anti-bacterial and anti-fungi properties of the oil were determine on clinical isolates of the organisms using agar diffusion method. The anti-inflammatory activities, cytotoxicity and anti-parasite potential were evaluated using lipooxygenase, mammalian cell and Toxoplasma gondii assays respectively. P. longifolia seed was observed to contain oleic (30.31%), linoleic acid (19.27%) and palmitic acid (15.11%) as the major fatty acids with low proportion of tricosylic acid (6.10) and stearic acid (5.56%). The oil had significant anti-lipooxygenase activity (IC50=0.70 +/- 0.02 mu g/mL) comparable to indomethacin (IC50=0.53 +/- 0.07 mu g/mL). The DPPH (IC50=55.91 +/- 31.18 mu g/mL) and ABTS (IC50=16.89 +/- 15.50 mu g/mL) antioxidant activity of the oil was lower to the ascorbic acid (IC50=0.34 +/- 0.04 and 0.54 +/- 0.04 mu g/mL). The oil also showed activities against all the tested bacteria and fungi. The highest inhibition was recorded against S. aureus (17 +/- 1mm) at concentration 200mg/mL. Further, the oils showed strong potential to restrict growth of Toxoplasma gondii in vitro, but the parasite growth inhibition was mildly abated in the presence of -tocopherol. The seed oil of the underutilized P. longifolia possesses essential fatty acids which could be responsible for the numerous biological potentials which include anti-lipooxygenase, antioxidant, anti-inflammatory, anti-parasite, anti-microbial and cytotoxic activities. The incorporation of the natural oil into pharmaceuticals or cosmetics may enhance antioxidant, anti-inflammatory, antimicrobial and cytotoxicity potential of such products.</description>
  </descriptions>
</resource>