1 Ocak 2014 Dergi makalesi Açık Erişim

Ergun, Sercan; Arman, Kaifee; Temiz, Ebru; Bozgeyik, Ibrahim; Yumrutas, Onder; Safdar, Muhammad; Dagli, Hasan; Arslan, Ahmet; Oztuzcu, Serdar

Dublin Core

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  <dc:creator>Ergun, Sercan</dc:creator>
  <dc:creator>Arman, Kaifee</dc:creator>
  <dc:creator>Temiz, Ebru</dc:creator>
  <dc:creator>Bozgeyik, Ibrahim</dc:creator>
  <dc:creator>Yumrutas, Onder</dc:creator>
  <dc:creator>Safdar, Muhammad</dc:creator>
  <dc:creator>Dagli, Hasan</dc:creator>
  <dc:creator>Arslan, Ahmet</dc:creator>
  <dc:creator>Oztuzcu, Serdar</dc:creator>
  <dc:date>2014-01-01</dc:date>
  <dc:description>Caspases are important initiators and most well-known finishers of apoptosis. By changing the death propagation homeostatic equilibrium, their different expression patterns might trigger the progression of hazardous diseases like cancer. miR-221 is an oncogenic miRNA. It is known to have both anti-angiogenic and angiogenic effect. The aim of this work was to compare the expression levels of miR-221 and its target caspase-3 in different cancer cell lines and to find out a relationship between these two. We also tried to establish a prominent relationship between miR-221 and its role in apoptosis by studying their expression levels. Our results indicate that expression of caspase-3 is quite lower as compared to miR-221 expression in all of the selected cancer cell lines. As a result, we conclude that miR-221 may have a crucial role in repressing the expression of caspase-3 which may contribute to a lower apoptotic rate, thus supporting the selection of more aggressive cancer cells. To our knowledge, this is the first study related to the expression levels of caspase-3 and miR-221 in different cell lines at the same time. We expect that our study might pave the way for better understanding the role of miR-221 in apoptotic regulation of caspase-3.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/63069</dc:identifier>
  <dc:identifier>oai:zenodo.org:63069</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>MOLECULAR BIOLOGY REPORTS 41(9) 5877-5881</dc:source>
  <dc:title>Expression patterns of miR-221 and its target Caspase-3 in different cancer cell lines</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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