1 Ocak 2014 Dergi makalesi Açık Erişim

Ergun, Sercan; Arman, Kaifee; Temiz, Ebru; Bozgeyik, Ibrahim; Yumrutas, Onder; Safdar, Muhammad; Dagli, Hasan; Arslan, Ahmet; Oztuzcu, Serdar

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{
  "DOI": "10.1007/s11033-014-3461-6", 
  "abstract": "Caspases are important initiators and most well-known finishers of apoptosis. By changing the death propagation homeostatic equilibrium, their different expression patterns might trigger the progression of hazardous diseases like cancer. miR-221 is an oncogenic miRNA. It is known to have both anti-angiogenic and angiogenic effect. The aim of this work was to compare the expression levels of miR-221 and its target caspase-3 in different cancer cell lines and to find out a relationship between these two. We also tried to establish a prominent relationship between miR-221 and its role in apoptosis by studying their expression levels. Our results indicate that expression of caspase-3 is quite lower as compared to miR-221 expression in all of the selected cancer cell lines. As a result, we conclude that miR-221 may have a crucial role in repressing the expression of caspase-3 which may contribute to a lower apoptotic rate, thus supporting the selection of more aggressive cancer cells. To our knowledge, this is the first study related to the expression levels of caspase-3 and miR-221 in different cell lines at the same time. We expect that our study might pave the way for better understanding the role of miR-221 in apoptotic regulation of caspase-3.", 
  "author": [
    {
      "family": "Ergun", 
      "given": " Sercan"
    }, 
    {
      "family": "Arman", 
      "given": " Kaifee"
    }, 
    {
      "family": "Temiz", 
      "given": " Ebru"
    }, 
    {
      "family": "Bozgeyik", 
      "given": " Ibrahim"
    }, 
    {
      "family": "Yumrutas", 
      "given": " Onder"
    }, 
    {
      "family": "Safdar", 
      "given": " Muhammad"
    }, 
    {
      "family": "Dagli", 
      "given": " Hasan"
    }, 
    {
      "family": "Arslan", 
      "given": " Ahmet"
    }, 
    {
      "family": "Oztuzcu", 
      "given": " Serdar"
    }
  ], 
  "container_title": "MOLECULAR BIOLOGY REPORTS", 
  "id": "63069", 
  "issue": "9", 
  "issued": {
    "date-parts": [
      [
        2014, 
        1, 
        1
      ]
    ]
  }, 
  "page": "5877-5881", 
  "title": "Expression patterns of miR-221 and its target Caspase-3 in different cancer cell lines", 
  "type": "article-journal", 
  "volume": "41"
}