1 Ocak 2014 Dergi makalesi Açık Erişim

Ergun, Sercan; Arman, Kaifee; Temiz, Ebru; Bozgeyik, Ibrahim; Yumrutas, Onder; Safdar, Muhammad; Dagli, Hasan; Arslan, Ahmet; Oztuzcu, Serdar

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        "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", 
        "name": "Ergun, Sercan"
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      {
        "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", 
        "name": "Arman, Kaifee"
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      {
        "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", 
        "name": "Temiz, Ebru"
      }, 
      {
        "affiliation": "Adiyaman Univ, Dept Med Biol, Fac Med, Adiyaman, Turkey", 
        "name": "Bozgeyik, Ibrahim"
      }, 
      {
        "affiliation": "Adiyaman Univ, Dept Med Biol, Fac Med, Adiyaman, Turkey", 
        "name": "Yumrutas, Onder"
      }, 
      {
        "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", 
        "name": "Safdar, Muhammad"
      }, 
      {
        "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", 
        "name": "Dagli, Hasan"
      }, 
      {
        "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", 
        "name": "Arslan, Ahmet"
      }, 
      {
        "affiliation": "Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey", 
        "name": "Oztuzcu, Serdar"
      }
    ], 
    "description": "Caspases are important initiators and most well-known finishers of apoptosis. By changing the death propagation homeostatic equilibrium, their different expression patterns might trigger the progression of hazardous diseases like cancer. miR-221 is an oncogenic miRNA. It is known to have both anti-angiogenic and angiogenic effect. The aim of this work was to compare the expression levels of miR-221 and its target caspase-3 in different cancer cell lines and to find out a relationship between these two. We also tried to establish a prominent relationship between miR-221 and its role in apoptosis by studying their expression levels. Our results indicate that expression of caspase-3 is quite lower as compared to miR-221 expression in all of the selected cancer cell lines. As a result, we conclude that miR-221 may have a crucial role in repressing the expression of caspase-3 which may contribute to a lower apoptotic rate, thus supporting the selection of more aggressive cancer cells. To our knowledge, this is the first study related to the expression levels of caspase-3 and miR-221 in different cell lines at the same time. We expect that our study might pave the way for better understanding the role of miR-221 in apoptotic regulation of caspase-3.", 
    "doi": "10.1007/s11033-014-3461-6", 
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    "journal": {
      "issue": "9", 
      "pages": "5877-5881", 
      "title": "MOLECULAR BIOLOGY REPORTS", 
      "volume": "41"
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      "id": "cc-by"
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    "publication_date": "2014-01-01", 
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      "title": "Dergi makalesi", 
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    "title": "Expression patterns of miR-221 and its target Caspase-3 in different cancer cell lines"
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