1 Ocak 2014 Dergi makalesi Açık Erişim

Ergun, Sercan; Arman, Kaifee; Temiz, Ebru; Bozgeyik, Ibrahim; Yumrutas, Onder; Safdar, Muhammad; Dagli, Hasan; Arslan, Ahmet; Oztuzcu, Serdar

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/63069</identifier>
  <creators>
    <creator>
      <creatorName>Ergun, Sercan</creatorName>
      <givenName>Sercan</givenName>
      <familyName>Ergun</familyName>
      <affiliation>Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Arman, Kaifee</creatorName>
      <givenName>Kaifee</givenName>
      <familyName>Arman</familyName>
      <affiliation>Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Temiz, Ebru</creatorName>
      <givenName>Ebru</givenName>
      <familyName>Temiz</familyName>
      <affiliation>Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bozgeyik, Ibrahim</creatorName>
      <givenName>Ibrahim</givenName>
      <familyName>Bozgeyik</familyName>
      <affiliation>Adiyaman Univ, Dept Med Biol, Fac Med, Adiyaman, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yumrutas, Onder</creatorName>
      <givenName>Onder</givenName>
      <familyName>Yumrutas</familyName>
      <affiliation>Adiyaman Univ, Dept Med Biol, Fac Med, Adiyaman, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Safdar, Muhammad</creatorName>
      <givenName>Muhammad</givenName>
      <familyName>Safdar</familyName>
      <affiliation>Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dagli, Hasan</creatorName>
      <givenName>Hasan</givenName>
      <familyName>Dagli</familyName>
      <affiliation>Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Arslan, Ahmet</creatorName>
      <givenName>Ahmet</givenName>
      <familyName>Arslan</familyName>
      <affiliation>Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oztuzcu, Serdar</creatorName>
      <givenName>Serdar</givenName>
      <familyName>Oztuzcu</familyName>
      <affiliation>Gaziantep Univ, Dept Med Biol, Fac Med, TR-27310 Sehitkamil, Gaziantep, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Expression Patterns Of Mir-221 And Its Target Caspase-3 In Different Cancer Cell Lines</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2014</publicationYear>
  <dates>
    <date dateType="Issued">2014-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/63069</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s11033-014-3461-6</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Caspases are important initiators and most well-known finishers of apoptosis. By changing the death propagation homeostatic equilibrium, their different expression patterns might trigger the progression of hazardous diseases like cancer. miR-221 is an oncogenic miRNA. It is known to have both anti-angiogenic and angiogenic effect. The aim of this work was to compare the expression levels of miR-221 and its target caspase-3 in different cancer cell lines and to find out a relationship between these two. We also tried to establish a prominent relationship between miR-221 and its role in apoptosis by studying their expression levels. Our results indicate that expression of caspase-3 is quite lower as compared to miR-221 expression in all of the selected cancer cell lines. As a result, we conclude that miR-221 may have a crucial role in repressing the expression of caspase-3 which may contribute to a lower apoptotic rate, thus supporting the selection of more aggressive cancer cells. To our knowledge, this is the first study related to the expression levels of caspase-3 and miR-221 in different cell lines at the same time. We expect that our study might pave the way for better understanding the role of miR-221 in apoptotic regulation of caspase-3.</description>
  </descriptions>
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